Preparation method of 3š�-succinyl-18-disodium salt dehydro ursolic acid

A technology of ursolic acid disodium salt and succinyl, which is applied in the field of preparation of 3β-succinyl-18-dehydroursolic acid disodium salt, can solve the problems such as undescribed preparation methods, and achieve low production cost and high product quality. The effect of convenient separation and purification and simple synthesis process
CN1446819AInactive Publication Date: 2003-10-08GUANGZHOU HANFANG PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGZHOU HANFANG PHARMA
Publication Date
2003-10-08
Estimated Expiration
Not applicable · inactive patent
Patent Text Reader

Abstract

A process for preparing 3 beta-succinyl-18-disodium dehydroursolate includes reaction between 18-dehydroursolic acid and succinic acid anhydride in alkaline organic solvent at 80-202 deg.C for 5-12 hr, adding diluted acid, filter, water washing to remove pyridine, dissolving in C1-14 emtrol or ethyl acetate, adding sodium hydroxide solution, filter, recrystallizing and drying. Its advantage is high purity (more than 95%).
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Description

Technical field

[0001] The invention belongs to a preparation method of pentacyclic triterpenoid compound 3β-succinyl-18-dehydroursolic acid disodium salt. Background technique:

[0002] 18-Dehydroursolic acid is a compound extracted from Ilex Pubescens Hook.et Arn. plants of the family Aquifoliaccae. Its properties are insoluble in water, so it is difficult to show physiological activity. Therefore, Convert 18-dehydroursolic acid into its a kind of pentacyclic triterpene compound 3β-succinyl-18-dehydroursolic acid disodium salt with strong physiological activity, thereby improving the solubility in water and showing obvious physiological activity .

[0003] A series of studies on the evaluation of pharmacy, efficacy, toxicology and clinical efficacy of 3β-succinyl-18-dehydroursolic acid disodium salt. The experimental studies have proved that it has a certain effect on platelet aggregation induced by ADP or epinephrine. It has a certain anticoagulant effect and good antib...

Claims

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