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Anti-cold oral drip-pill and preparing process

A preparation process and technology of dripping pills, applied in the directions of anti-infective drugs, anti-inflammatory agents, pill delivery, etc., can solve problems such as insufficient efficacy, and achieve the effects of increased bioavailability, small dosage, and rapid efficacy.

Inactive Publication Date: 2004-02-11
彭红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no oral drop pill made of the three medicinal materials of the anti-gan prescription, and its effectiveness has not been fully exerted.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Add 210g of honeysuckle, 210g of Radix Paeoniae Rubra, and 70g of Mianmaguanzhong, add 5 times the amount of water and decoct twice for 1.5 hours each time, combine the decoction, filter, concentrate the filtrate to 250ml, add ethanol until the alcohol content is 50% , stir, stand overnight, filter, recover ethanol, concentrate to dryness, add polyethylene glycol 6000 100g, sodium stearate 10g, poloxamer 5g, heat, melt and mix well, and then dry At -80°C, drop it into the condensation of simethicone oil at a rate of 50 drops per minute. After forming, take it out, remove the condensing agent, check the amount of ingredients, pass it, pack it, and get the finished product. Every 1000 servings of Kanggan Oral Dropping Pills contains 210g of honeysuckle, 210g of red peony, and 70g of Mianmaguanzhong extract.

Embodiment 2

[0015] Add 210g of honeysuckle, 210g of Radix Paeoniae Rubra, and 70g of Mianmaguanzhong, add 5 times the amount of water and decoct twice for 1.5 hours each time, combine the decoction, filter, concentrate the filtrate to 250ml, add ethanol until the alcohol content is 50% , stirred, left overnight, filtered, recovered ethanol, concentrated to dryness to obtain dry extract, added polyethylene glycol 4000 100g, sodium stearate 20g, heated and melted and mixed, at 60°C-80°C , drop into the simethicone oil condensation at a rate of 30 drops per minute, take it out after forming, remove the condensing agent, check the amount of ingredients, pass the test, pack it, and get the finished product. Every 1000 servings of Kanggan Oral Dropping Pills contains 210g of honeysuckle, 210g of red peony, and 70g of Mianmaguanzhong extract.

Embodiment 3

[0017] Add 210g of honeysuckle, 210g of Radix Paeoniae Rubra, and 70g of Mianmaguanzhong, add 5 times the amount of water and decoct twice for 1.5 hours each time, combine the decoction, filter, concentrate the filtrate to 250ml, add ethanol until the alcohol content is 50% , stir, stand overnight, filter, recover ethanol, concentrate to dryness, and after obtaining dry extract, add polyoxyethylene monostearate 100g, glyceryl monostearate 60g, poloxamer 10g, heat and melt , after mixing, in the state of 60°C-80°C, drip into the camellia oil at a rate of 20 drops per minute, after forming, take it out, remove the condensing agent, check the component amount, pass it, pack it, and get the finished product. Every 1 000 servings of Kanggan Oral Dropping Pills contains 210g of honeysuckle, 210g of Radix Paeoniae Rubra, and 70g of Mianmaguanzhong extract.

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PUM

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Abstract

The present invention discloses anti-cold oral drip pill and its preparation process. The anti-cold oral drip pill has honeysuckle, red peony root and basket fern rhizome extractive as active components and proper amount of matrix. The matrix is polyglycol-6000, polyglycol-4000, polyethylene glycol monostearate, sodium stearate, glyceryl glutin, poloxamer, stearic acid, glyceryl monostearate, insect wax or their mixture. The preparation process includes twice decoction of honeysuckle, red peony root and basket fern rhizome, filtering, concentration, mixing the filtrate with alcohol via stirring, setting, filtering, concentration to obtain dry extractum, mixing with matrix while heating, dripping into condensating agent, taking out, inspection and packing, with the condensating agent beingdimethyl silicon oil, liquid paraffin, tea oil, rape seed oil, gasoline or their mixture.

Description

technical field [0001] The invention relates to an oral dripping pill, in particular to an anti-gan oral dripping pill for treating cold diseases and a preparation method thereof. Background technique [0002] The Kanggan prescription is composed of three traditional Chinese medicines: honeysuckle, red peony root, and Mianma Guanzhong. It has the effect of clearing heat and detoxifying; it is used for fever, headache, nasal congestion, sneezing, sore throat, malaise and soreness caused by exogenous wind-heat. Kanggan Oral Dropping Pills refers to a preparation made by boiling and extracting three traditional Chinese medicines, ethanol precipitation, concentration and drying, heating, melting and mixing with related substrates, then dropping them into an immiscible condensing agent, shrinking and cooling. It is characterized by small dosage, high bioavailability of traditional Chinese medicine ingredients, quick drug effect, small side effects, easy to take and transport, in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P29/00A61P31/00
Inventor 彭红许军
Owner 彭红
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