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Eye preparation formula adapted for therapentic medicine

A drug and formula technology, applied in the field of ophthalmic preparations suitable for therapeutic drugs, can solve the problems of short residence time and low bioavailability, and achieve the effects of enhancing response, eliminating eye irritation and reducing the number of medication

Inactive Publication Date: 2004-03-24
JC (WUXI) CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (2) Therapeutic drugs such as ofloxacin stay on the surface of the eye for a short time and have low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0029] This modified ophthalmic formulation of ofloxacin is also formulated as sterile, isotonic eye drops in water. The prescription contained 0.30% ofloxacin, 0.005% benzalkonium chloride, sodium chloride, disodium hydrogen phosphate and monobasic sodium phosphate, Pluronic F-127, and purified water. If necessary, add sodium hydroxide to adjust the pH to 6.2---6.6.

[0030] This formulation uses a heteromolecular polymer consisting of ethylene oxide and propylene oxide. The use of Pluronic F-127 will result in less eye irritation of the final product with the same or even better efficacy. The pharmaceutical components mentioned in the prescription of claim 1 may be anti-infective drugs such as antifungal agent natamycin, antiviral agents, antibiotics such as tobramycin, ciprofloxacin and ofloxacin, etc.

[0031] Component

experiment example 2

[0033] Component

experiment example 3

[0035] Component

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PUM

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Abstract

The present invention relates to a kind of eye drops containing effective therapeutic medicines of ofloxacin, etc. and medicinal auxiliary material. Said invention selects and uses heteromolecule copolymer high-molecular material and buffer nutrient system to lubricate and nurture eyeball and prolong the retention time of the eye drops on the surface of eyeball so as to raise the biological utilization rate. Said eye drops preparation can be better spread on the surface of eyeball, and can reduce and eliminate the irritation of the eye drops to the eye and burning sensation.

Description

technical field [0001] The present invention uses heteromolecular copolymerized polymer materials and a buffer nutrition system to lubricate and nourish the eyeball and prolong the retention time of eye drops such as ofloxacin and other therapeutic drugs on the surface of the eyeball, reducing or eliminating the stinging and pain of eye preparations on the eyes. burning sensation. Background technique [0002] So far, ophthalmic preparations of therapeutic drugs have always been the leading products in ophthalmic preparations in the international market. In our country, such ophthalmic preparations are even more dominant. Therefore, no matter in the United States or in China, there are many eye preparations designed for therapeutic drugs on the market. Take the ofloxacin eye drops with the trade name OCUFLOX produced by Allergan, an American ophthalmic preparation company of a well-known multinational company, as an example. / kg. [0003] Component W / V% ...

Claims

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Application Information

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IPC IPC(8): A61K31/5383A61K45/00A61K47/30A61P11/02A61P27/02A61P27/16
Inventor 程景才
Owner JC (WUXI) CO INC
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