Compounding use of sodium hyaluronate for eye preparation

A technology of sodium hyaluronate and preparations, applied in the field of pharmaceuticals, to achieve the effects of being conducive to full absorption and utilization, increasing stability and water holding capacity, and long residence time

Inactive Publication Date: 2004-04-14
刘继东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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Examples

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Effect test

example 1

[0011] Example 1. An ophthalmic formulation for the treatment of external eye infection, containing quinolone antibacterial and anti-inflammatory drugs ciprofloxacin hydrochloride, with sodium hyaluronate and glycerin as a composite matrix. The formula consists of the following:

[0012] Components: Ciprofloxacin hydrochloride 3.0‰, boric acid 11.8‰, sodium hyaluronate 2.0‰, glycerin 5.0‰, benzalkonium chloride 0.15‰, and the remaining ingredients are water for injection.

[0013] Preparation process: Dissolve the prescribed amount of sodium hyaluronate in water for injection at room temperature, filter and add to the blending tank; take another water for injection to dissolve glycerin, boric acid and benzalkonium chloride, dissolve ciprofloxacin hydrochloride, and confirm the dissolution of the raw materials If it is completely dissolved, add it to the blending tank, stir well, add water to the full amount, filter, fill, pack, and get ready.

example 2

[0014] Example 2. A kind of ophthalmic preparation formulation for the treatment of external eye infection, containing quinolones antibacterial and anti-inflammatory drug ofloxacin, with sodium hyaluronate and glycerin as composite matrix. The formula consists of the following:

[0015] Components: ofloxacin 3.0‰, sodium hyaluronate 2.0‰, glycerin 5.0‰, sodium chloride 2.0‰, boric acid 20.0‰, benzalkonium chloride 0.1‰, and the rest is water for injection.

[0016] Preparation process: Dissolve sodium hyaluronate in water for injection at room temperature, filter and add to the blending tank; take another water for injection to dissolve boric acid, benzalkonium chloride, glycerin, and sodium chloride in sequence, and after fully dissolved, add the prescribed amount of oxygen The floxacin is fully stirred and heated to boil to make it completely dissolved, mixed, replenished with water to the full amount, filtered, filled, packaged, and the product is obtained.

example 3

[0017] Example 3. A kind of ophthalmic preparation formula that eliminates eye congestion and swelling, is used for the treatment of allergic or inflammatory conjunctival hyperemia, swelling, and is also used for keratitis, eye diseases such as conjunctivitis, dry eyes, and external eye infection, containing The decongestant drug naphazoline hydrochloride uses sodium hyaluronate and glycerin as a composite matrix. The formula consists of the following:

[0018] Components: naphazoline hydrochloride 0.12‰, borax 6.5‰, boric acid 10.0‰, sodium hyaluronate 3.0‰, benzalkonium chloride 0.15‰, glycerin 5.0‰, appropriate amount of cooling agent, and the rest is water for injection.

[0019] Preparation process: take water for injection at room temperature, dissolve the prescribed amount of sodium hyaluronate; take another water for injection, first dissolve benzalkonium chloride, then dissolve the prescribed amount of boric acid, borax, glycerin in sequence, dissolve naphazoline hydr...

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Abstract

The invention refers to the compound applied technique of two components of adjunct medical material-sodium hyaluronate and glycerin, in ophthalmic preparation. Its main technique: the compound base material is added to the ophthalmic preparation to make into stable water-soluble transparent eye drops; sodium hyaluronate is 0.05%-0.5% (g/ml) and glycerin 0.1%-2.5% (g/ml), and the mixed proportion: the former : the latter=1:1-1:4, and the optimal project: the former 0.05%-0.25%, the latter 0.1%-0.5%, and the mixed proportion: 1:2-1:4, and they can be added in multiple eye drops.

Description

Technical field [0001] The invention belongs to the technical field of medicines. The present invention relates to the composite application technology of two pharmaceutical excipients—sodium hyaluronate (also known as sodium hyaluronate) and glycerin—in ophthalmic preparations, which are applied to conventional ophthalmic preparations. Sodium hyaluronate belongs to mucopolysaccharide compounds , transparent, non-inflammatory, viscous and elastic, sodium hyaluronate plays an important role in the body through physical functions such as viscoelasticity and high hydration, as well as physiological functions of interacting with receptors. Background technique [0002] Medicines for treating eye diseases are usually prepared in the form of liquid preparations or creams and administered in the form of eye drops. In Europe or some other countries (Japan, the United States), there are products that use sodium hyaluronate or glycerin alone as ophthalmic preparations. There are few ...

Claims

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Application Information

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IPC IPC(8): A61K31/165A61K31/196A61K31/255A61K31/4168A61K31/4196A61K31/496A61K31/5383A61K31/7028A61K47/36
Inventor 刘继东高峨马风明姚东民宋长海刘立新
Owner 刘继东
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