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Calcium phosphate composite powder and preparing method thereof

A composite powder and calcium phosphate technology, which is applied in the treatment of dyed polymer organic compounds and fibrous fillers, can solve the problems of inability to obtain implant effects, the degradation rate of tricalcium phosphate affecting the osseointegration ability of implants, and low solubility , to achieve the effect of easy preparation process conditions, low cost and uniform particle size distribution

Inactive Publication Date: 2004-04-14
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After hydroxyapatite is implanted into the human body, due to its very low solubility, the best implantation effect cannot be obtained; and the degradation rate of tricalcium phosphate is too high, which will also affect the osseointegration ability of the implant

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] A certain proportion of polyethylene glycol (PEG) and CaCl 2 (PEG:CaCl 2 =3:1, molar ratio, the polymer is calculated by the number of moles of structural units, the same below) is dissolved in 200ml of distilled water, Na 3 PO 4 12H 2 O was dissolved in 100ml of distilled water, the molar ratio of Ca / P was 1.60, stirred and dissolved, and placed in refrigeration at 5°C. After the temperature stabilized, the two solutions were mixed at 5° C., adjusted to pH 10 with ammonia water, and reacted for 30 minutes under magnetic stirring. The precipitate was suction filtered, washed, and freeze-dried for 48 hours to obtain a calcium phosphate precursor. The calcium phosphate precursor is raised to 800°C at a heating rate of 10°C / min for 3 hours, and then lowered to room temperature with the furnace, and the content of hydroxyapatite is 60%, and the content of α-phase tricalcium phosphate is 40%. calcium phosphate composite powder.

Embodiment 2

[0014] A certain proportion of polyvinyl alcohol (PVA) and CaCl 2 (PVA: CaCl 2 =3:1, molar ratio) was dissolved in 200ml of distilled water, Na 3 PO 4 12H 2 O was dissolved in 100ml of distilled water, reacted at 50°C, the Ca / P molar ratio was 1.60, the pH was adjusted to 10 with ammonia water, and reacted for 30 minutes under magnetic stirring. The precipitate was suction filtered, washed, and freeze-dried for 48 hours to obtain a calcium phosphate precursor. The calcium phosphate precursor is raised to 800°C at a heating rate of 10°C / min for 3 hours, and then lowered to room temperature with the furnace, and the content of hydroxyapatite is 60%, and the content of β-phase tricalcium phosphate is 40%. calcium phosphate composite powder.

Embodiment 3

[0016] A certain proportion of PEG and CaCl 2 (PEG:CaCl 2 =3:1, molar ratio) was dissolved in 200ml of distilled water, Na 3 PO 4 12H 2 O was dissolved in 100ml of distilled water, the Ca / P molar ratio was 1.50, stirred and dissolved, and placed in a refrigerator at 5°C. After the temperature stabilized, the two solutions were mixed at 5° C., adjusted to pH 9 with ammonia water, and reacted for 30 minutes under magnetic stirring. The precipitate was suction filtered, washed, and freeze-dried for 48 hours to obtain a calcium phosphate precursor. The calcium phosphate precursor is raised to 800°C at a heating rate of 10°C / min and kept at 800°C for 3 hours, and then lowered to room temperature with the furnace, and the content of β-phase tricalcium phosphate is 50%, and the content of α-phase tricalcium phosphate is 50%. % calcium phosphate composite powder.

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Abstract

The present invention discloses a kind of calcium phosphate composite powder and its preparation method. Adopting wet chemical method and controlling technological condition to synthesize calcium phosphate precursor with different Ca / P ratios, then through heat treatment to obtain the hydroxyapatite and / or alpha-phase tricalcium phosphate composite powder, hydroxyapatite and / or beta-phase tricalcium phospate composite powder or alpha-phase tricalcium phosphate composite powder and / or beta-phase tricalcium phosphate composite powder whose ratios can be arbitrarily regulated. The invented granule distribution is uniform, and its granule size is 50nm-500nm, it can be used in the bio-medicinal material field extensively.

Description

technical field [0001] The invention relates to a biomedical calcium phosphate composite powder and a preparation method thereof. Background technique [0002] Calcium phosphate materials are a class of ceramics widely used as hard tissue replacement materials. Calcium phosphate materials mainly include α-phase tricalcium phosphate (α-Ca 3 (PO 4 ) 2 , α-TCP), β-phase tricalcium phosphate (β-Ca 3 (PO 4 ) 2 , β-TCP), hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HA). They each have different advantages: hydroxyapatite has excellent biological activity and osteoconductivity; α-phase tricalcium phosphate and β-phase tricalcium phosphate have biological activity and good biodegradation rate. After hydroxyapatite is implanted into the human body, due to its very low solubility, the best implantation effect cannot be obtained; and the degradation rate of tricalcium phosphate is too high, which will also affect the osseointegration ability of the impl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09C1/02C09C3/10
Inventor 翁文剑李延报韩高荣杜丕一程逵沈鸽赵高凌张溪文
Owner ZHEJIANG UNIV
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