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Traditional Chinese medicine composition for blahs and anxiety

A composition and anxiety technology, applied in their treatment field, can solve the problems of expensive, toxic and side effects

Inactive Publication Date: 2004-06-02
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing antidepressants are mainly: tricyclics (TCAs), selective 5-HT reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), they all have different degrees of toxic and side effects, and are expensive, etc. shortcoming

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Example 1 Research on the antidepressant effect of "Xinyue" and its mechanism of action

[0009] 1 Materials and methods

[0010] 1.1 Animals Kunming mice, male, weighing 18-22 g. Provided by the Experimental Animal Center of the Academy of Military Medical Sciences. The mice in each group were given free access to water, food and natural light under the same conditions.

[0011] 1.2 Drugs Ginseng, Poria cocos, Shichangpu, Polygala (3:3:2:2) were purchased from the Chinese Pharmacy Department of the PLA General Hospital, soaked in water for 30 minutes, decocted for 30 minutes, and the combined filtrate was concentrated twice to contain 1g of crude drug per 1ml, 4 ℃ refrigerator. Positive drug DESIPRAMINE (SIGMA company, lot number: 200-373-1). The cortisol kit was provided by East Asia Institute of Immunology. Standard substance: norepinephrine (Norepinephrine, NE, Sigma Company, batch number; 200-095-0); dopamine (Dopamine, DA, Sigma Company, batch number: 200-527-...

Embodiment 2

[0085] Example 2 Clinical Impression Observation of Depression Treated by Xinyue

[0086] 1. Diagnostic criteria

[0087] The subjects came from the Psychological Consultation Clinic of the Department of Neurology. We used the Zung Self-Rating Depression Scale (SDS) and the Self-Rating Depressive Symptom Scale (Wakefield Form) to evaluate once before administration. Those with secondary depression caused by physical diseases were excluded as observation objects. After administration, the same evaluation table was used to evaluate once, and the clinical curative effect was evaluated according to 4 grades.

[0088] A total of 16 patients, 11 males, 5 females, aged 21 to 52 years, 4 junior high school education, 3 high school, 9 junior college or above, blood, urine routine, liver, kidney function and electrocardiogram examination before treatment.

[0089] 2. Method:

[0090] After the patient came for consultation, he stopped using other antidepressants for 7 days, and then ...

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Abstract

The present invention is one kind of Chinese medicine composition, named Xinyue, with obvious treating effect on depression and anxiety neurosis. The Chinese medicine composition is the mixture of ginseng, tuckahoe, grassleaved sweetflag rhizome and polygala root in certain proportion or the mixture of their active components extracted, and may be prepared into various preparation forms. It is suitable for depression and anxiety neurosis caused by different reasons, and has the action mechanism of raising the content of NE, 5-HT and metabolism product 5-HIAA in body, activating the 5-HT neuron in brain and lowering the content of corticosteroid in depression blood plasma.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and mainly provides a traditional Chinese medicine composition with obvious antidepressant effect composed of ginseng, Poria cocos, Shichangpu and polygala, and various medicines obtained by extracting, concentrating and refining The active ingredient is a composition composed of ginsenoside, pachymansin, volatile / non-volatile ingredient of calamus calamus, polygala saponin or / and polysaccharide. It specifically relates to their application in treating depression and anxiety symptoms caused by various reasons and their application in preparing antidepression and anxiety products. Its antidepressant effect is related to the reduction of cortisol concentration in plasma of depressed animals and the increase of NE, 5-HT and its metabolite 5-HIAA in the brain. technical background [0002] According to the survey of WHO, the incidence rate of depression is as high as 10%, ranking fifth am...

Claims

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Application Information

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IPC IPC(8): A61P25/22A61P25/24
Inventor 刘屏陈孟莉周晓青陈宜鸿王东晓袁默王波汪进良任浩洋
Owner GENERAL HOSPITAL OF PLA
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