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Water-soluble matrix for external transdermal paster and preparing method thereof

A technology of water-soluble matrix and transdermal patch, applied in the field of water-soluble matrix of external transdermal patch and its preparation, can solve the problems of high price, poor adhesion, impossibility of popularization and use, etc. The effect of strong sex and reducing individual differences

Inactive Publication Date: 2004-09-15
马田田
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its high price and poor adhesion, this new transdermal preparation cannot be widely promoted and used.

Method used

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  • Water-soluble matrix for external transdermal paster and preparing method thereof
  • Water-soluble matrix for external transdermal paster and preparing method thereof
  • Water-soluble matrix for external transdermal paster and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] It is made of the following raw materials in weight ratio: polyacrylic acid and sodium polypropylene copolymer: polyvinylpyrrolidone: polyvinyl alcohol: glycerin: potassium hydroxide: tartaric acid = 3: 2: 2: 15: 0.3: 0.2.

[0036] Its preparation method is:

[0037] a. Get 2kg of polyvinylpyrrolidone to make a 12% aqueous solution;

[0038] b. Get 2kg of polyvinyl alcohol to make a 10% aqueous solution;

[0039] C. get tartaric acid 0.2kg to make content and be the aqueous solution of 0.1%;

[0040] d. Fully mix the prepared polyvinylpyrrolidone aqueous solution, organic acid aqueous solution, enol aqueous solution, polyacrylic acid and polypropylene sodium copolymer 3kg, glycerin 15kg and potassium hydroxide 0.3kg, stir evenly, and place to form a matrix .

Embodiment 2

[0042] It is made of the following raw materials in weight ratio: polyacrylic acid and sodium polypropylene copolymer: polyvinylpyrrolidone: polyvinyl alcohol: glycerin: sodium hydroxide: tartaric acid=12:10:10:75:2.5:1.5.

[0043] The preparation method is the same as in Example 1.

Embodiment 3

[0045] It is made of the following raw materials in weight ratio: polybutacrylic acid and sodium polybutene copolymer: polyvinylpyrrolidone: polyvinyl alcohol: glycerin: potassium hydroxide: tartaric acid = 8: 8: 6: 50: 1: 0.5 .

[0046] Its preparation method is: a. take polyvinylpyrrolidone 8kg to make the aqueous solution that content is 16%;

[0047] B. get polyvinyl alcohol 6kg to make content be the aqueous solution of 16%;

[0048] C. getting tartaric acid 0.5kg to make content is the aqueous solution of 0.5%;

[0049] d. Fully mix the polyvinylpyrrolidone aqueous solution, organic acid aqueous solution, enol aqueous solution, polybutacrylic acid and polybutene sodium copolymer 8kg, glycerin 50kg and potassium hydroxide 1kg prepared above, stir evenly, place, that is into a matrix.

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Abstract

The present invention discloses a water-soluble matrix of transdermal emplastrum for external application. It is formed from the following raw materials according a certain weight ratio: olefine acids and salts copolymer; polyvinylpyrrolidone: olefinic alcohols: glycerine: hydroxide: organic acid=(3-12):(2-10):(2-10):(15-75):(0.3-2.5):(0.2-1.5). Its preparation method is characterized by that the aqueous solution of polyvinylpyrro-lidone, aqueous solution of organic acid, aqueous solution of olefinic alcohols and olefine acids and salts copolymers, glycerine and hydroxide are fully mixed and stirred uniformly so as to can obtain the invented matrix. It has high biological utilization rate of medicine, and has good compatibility with water-soluble and fat-soluble medicines.

Description

technical field [0001] The invention relates to a drug carrier matrix capable of carrying water-soluble and fat-soluble Chinese and Western medicines and transdermal absorption accelerators, in particular to a water-soluble matrix of an external transdermal patch and a preparation method thereof. Background technique [0002] External drug patches have been used to treat arthritis, soft tissue injuries, bone hyperplasia, neuralgia and other diseases. They have a long history in China, such as traditional black plasters, modern rubber plasters, and pressure-sensitive adhesives. Although these traditional plasters have the advantages of convenience, local fast and effective, and reduced toxic and side effects, but because the black plaster contains a large amount of lead oxide, it has heavy metal toxicity; the rubber matrix has skin irritation; the high temperature during the preparation of the pressure-sensitive adhesive is easy to cause The loss of volatile medicines; and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/32A61M37/00
Inventor 马田田
Owner 马田田
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