Water-soluble matrix for external transdermal paster and preparing method thereof

Abstract

The present invention discloses a water-soluble matrix of transdermal emplastrum for external application. It is formed from the following raw materials according a certain weight ratio: olefine acids and salts copolymer; polyvinylpyrrolidone: olefinic alcohols: glycerine: hydroxide: organic acid=(3-12):(2-10):(2-10):(15-75):(0.3-2.5):(0.2-1.5). Its preparation method is characterized by that the aqueous solution of polyvinylpyrro-lidone, aqueous solution of organic acid, aqueous solution of olefinic alcohols and olefine acids and salts copolymers, glycerine and hydroxide are fully mixed and stirred uniformly so as to can obtain the invented matrix. It has high biological utilization rate of medicine, and has good compatibility with water-soluble and fat-soluble medicines.

Description

technical field

[0001] The invention relates to a drug carrier matrix capable of carrying water-soluble and fat-soluble Chinese and Western medicines and transdermal absorption accelerators, in particular to a water-soluble matrix of an external transdermal patch and a preparation method thereof. Background technique

[0002] External drug patches have been used to treat arthritis, soft tissue injuries, bone hyperplasia, neuralgia and other diseases. They have a long history in China, such as traditional black plasters, modern rubber plasters, and pressure-sensitive adhesives. Although these traditional plasters have the advantages of convenience, local fast and effective, and reduced toxic and side effects, but because the black plaster contains a large amount of lead oxide, it has heavy metal toxicity; the rubber matrix has skin irritation; the high temperature during the preparation of the pressure-sensitive adhesive is easy to cause The loss of volatile medicines; and th...

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