Combined sustained release agent and preparation thereof for preventing and treating livestock helminth, acarid and ectosarc disease

A protozoal disease and slow-release technology, applied in the field of medicaments for preventing and treating parasitic diseases of livestock and their preparation, can solve the problems of easy crystallization and precipitation of drugs, unstable cure rate, low drug inclusion rate, etc. Good control effect, wide insect repellent effect

Inactive Publication Date: 2004-11-10
ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of developing the combined sustained-release agent, the difficulty encountered is that the drug inclusion rate is low, generally only about 57%, and the drug is easy to crystallize out, resulting in unstable cure rate and poor effect in the application test of the product and other phenomena

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The combined sustained-release agent for preventing and treating Fasciola hepatica, nematodes, tapeworms, mites and protozoa diseases is prepared according to the following process conditions:

[0023] (1) Take 500 grams of iodosamide powder + 1000 milliliters of solvent acetone → shake until the medicine is completely dissolved into a transparent liquid;

[0024] (2) Grind 1,000 grams of powdered β-cyclodextrin + 4,000 ml of distilled water or deionized water for 20 minutes to form a paste;

[0025] (3) Pour the closamide solution into the pasty β-cyclodextrin, stir for 30 minutes, and continue inclusion at room temperature for 30 minutes;

[0026] (4) Mix 500 grams of powdered trypanocidal and pyrozoan agent Bernier + 10,000 milliliters of distilled water or deionized water → shake until the medicine is completely dissolved into a transparent liquid;

[0027] (5) Pour the Bernier solution into the above-mentioned inclusion compound of iodoclosamide and β-cyclodextrin...

Embodiment 2

[0029] (1) 500 grams of powdered drug iodosamide + 3000 milliliters of solvent acetone → shake until the medicine is completely dissolved into a transparent liquid;

[0030] (2) Grind 1,000 grams of powdered β-cyclodextrin + 6,000 ml of distilled water or deionized water for 40 minutes to form a paste;

[0031] (3) Pour the iodosamide solution into the pasty β-cyclodextrin, stir for 60 minutes, and continue inclusion at room temperature for 40 minutes;

[0032] (4) Mix 500 grams of powdered Bernier + 12000 milliliters of distilled water or deionized water → shake until the medicine is completely dissolved into a transparent liquid;

[0033] (5) Pour the Bernier's solution into the above-mentioned inclusion compound of iodoclosamide and β-cyclodextrin, stir for 70 minutes, put the solvent at 30-40°C to evaporate, evaporate the water until dry, and pulverize for 20 seconds Finally, sieve through 80-90 meshes to form the combined sustained-release powder product, which is packag...

Embodiment 3

[0035] (1) 500 grams of the powdered drug iodosamide + 2000 milliliters of solvent ethanol → shake until the medicine is completely dissolved into a transparent liquid;

[0036] (2) Grind 1,000 grams of powdered β-cyclodextrin + 5,000 ml of distilled water or deionized water for 30 minutes to form a paste;

[0037] (3) Pour the closamide solution into the pasty β-cyclodextrin, stir for 50 minutes, and continue inclusion at room temperature for 30 minutes;

[0038] (4) Mix 500 grams of powdered Bernier + 11,000 milliliters of distilled water or deionized water → shake until the medicine is completely dissolved into a transparent liquid;

[0039] (5) Pour the Bernier solution into the above-mentioned inclusion complex of iodoclosamide and β-cyclodextrin, stir for 50 minutes, place at 30-40°C to evaporate the solvent, evaporate the water until dry, and pulverize for 20 seconds Finally, sieve through 80-90 meshes to form the combined sustained-release powder product, which is pac...

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PUM

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Abstract

The invention discloses a combination slow release preparation for prevention and cure of livestock helminth, acarid and protozoon diseases, and the process for preparation comprising the steps of, using closantel and beta-cyclodextrin as the principal raw materials, carrying out rationalized proportioning and certain technological conditions, dissolving the closantel in solvent, charging distilled water into the beta-cyclodextrin, grinding till pasty state, mixing the two, drying and disintegrating.

Description

technical field [0001] The invention relates to a medicament for preventing and treating livestock parasitic diseases and a preparation method thereof, in particular to a combined slow-release agent for preventing and treating fasciola hepatica, nematodes, tapeworms, mites and protozoa and a preparation method thereof. Background technique [0002] Fasciola hepatica, nematode, tapeworm (the same genus of worm), mite and protozoa (including trypanosomiasis and pyroclion) are common parasitic diseases of livestock, which are widely prevalent in southern my country and are on the rise year by year. Livestock are often co-infected with these parasitic diseases, resulting in emaciated livestock, reduced meat production, reduced milk production of dairy cows, and loss of farming ability of farm cattle, seriously affecting the healthy development of animal husbandry. In order to control the above-mentioned parasitic diseases, the common single-dose closanta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/40A61K31/275A61P33/00A61K9/14
CPCY02A40/70
Inventor 张雪娟冯尚连孙仁寅袁国华方兰勇
Owner ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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