Tilmisartan salt and its prepn

A technology of telmisartan and sodium salt, which is applied in the field of telmisartan salt and its preparation, can solve the problems of low solubility, low dissolution rate and strong water absorption of telmisartan raw materials, and achieve high promotion and application prospects , High dissolution rate, easy preparation
CN1548421AInactive Publication Date: 2004-11-24SHANGHAI INST OF PHARMA IND
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI INST OF PHARMA IND
Publication Date
2004-11-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The Tilmisartan salt of the present invention is salt formed with Tilmisartan and alkali metal, alkali earth metal, pharmaceutically acceptable amine, amino acid. It may be sodium salt, potassium salt, calcium salt, magnesium salt and amine salt, preferably sodium salt, potassium salt or tert-butyl amine salt. The preparation of Tilmisartan salt includes the following steps: reaction between Tilmisartan and organic alkali, inorganic alkali, arginine or lysine in organic solvent or water to produce target product, and collecting Tilmisartan salt. The Tilmisartan salt may be used to replace available Tilmisartan.
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Description

technical field

[0001] The invention relates to a telmisartan salt and a preparation method thereof. Background technique

[0002] European patent EP502314B1 discloses a compound, telmisartan, and discloses a general structural formula, as follows:

[0003]

[0004] Telmisartan and its physiologically acceptable salts have valuable pharmacological properties. It is an angiotensin II antagonist, which due to its pharmacological properties can be used in the treatment of hypertension and myocardial insufficiency, in the treatment of ischemic peripheral circulation diseases, myocardial ischemia (angina).

[0005] Telmisartan crude drug solubility is less, after making preparation, its dissolution rate is lower, and patent CN1336920A once reported that telmisartan is dissolved in 0.1mol / L NaOH, is transformed into a kind of homogeneous and completely free by spray drying. Qualitative particles, but the samples prepared by this method are more hygroscopic. Contents of the ...

Claims

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