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Preparation of solanine sulfurate and its use in medicine

A technology of solanamine sulfate and Australian solanamine, which is applied in the field of Australian solanamine sulfate and its preparation and application in medicine, can solve the problems of raising blood sugar, and the preparation method has not been found yet, and achieves short production cycle and high source Rich and cheap, strong medicinal effect

Inactive Publication Date: 2004-12-08
刘良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] At home and abroad, there are chemical components of Solanum solanum, Solanum solanum and Solanaceae chrysanthemum, detection methods of solanamine and anti-S 180 , anti-inflammation, and blood sugar-increasing effects, but there is no information on the preparation method of Australian solanamine sulfate and the application of Australian solanamine sulfate in medicine.

Method used

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  • Preparation of solanine sulfurate and its use in medicine
  • Preparation of solanine sulfurate and its use in medicine
  • Preparation of solanine sulfurate and its use in medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1 Preparation of Australian solanamine sulfate with Solanum nigrum as raw material

[0059] With reference to Fig. 1, prepare the preparation method of Australian solanamine sulfate with nightshade fruit as follows:

[0060] (1) Take by weighing 500kg mid-October to the late October nightshade fruit to remove sundries, pulverize solid-liquid separation with a refiner to obtain fruit juice, pomace, and Solanum nigrum pomace is leached with 3% acetic acid aqueous solution for 2 Second, solid-liquid weight ratio 1:1, solid-liquid separation to obtain infusion, combined juice and infusion, set aside to settle, take the supernatant and heat to boiling, remove the floating green colloid, filter and cool, place the filtrate to settle, take the upper When the supernatant was heated to 80°C, concentrated ammonia water was added to pH8, the supernatant was removed by cooling and sedimentation, and the turbid liquid was centrifuged for solid-liquid separation to obtain the...

Embodiment 2

[0065] Example 2 Preparation of Australian Solanamine Sulfate Using Solanum Solanum as Raw Material

[0066] Get 500kg yellow fruit eggplant fruit, obtain Australian solanamine by the preparation method of embodiment 1 (1)-(4), take Australian solanamine 182g, with 95% ethanol it is all dissolved solid-liquid weight ratio 1: 30, heat Slowly add 36% sulfuric acid aqueous solution under boiling and stirring until it becomes acidic, place it to cool fully, make the crystals separate out and filter with suction, wash with 95% ethanol until neutral, and dry to obtain 254g of Australian solanamine sulfate, the purity is determined by high performance liquid chromatography was 97.4%.

Embodiment 3

[0067] Example 3 Preparation of Australian Solanamine Sulfate with Australian Solanum as Raw Material

[0068] Take 500kg of Australian solanum fruit, according to the preparation method of Example 1 (1)-(4) to obtain Australian solanamine, weigh 100g of Australian solanamine, heat and dissolve with 3000ml95% ethanol until boiling, slowly add 40% The sulfuric acid aqueous solution was left to cool overnight and suction filtered, washed with 95% ethanol until neutral, and dried to obtain 103 g of solanamine sulfate, the purity of which was determined by high performance liquid chromatography to be 98.1%.

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Abstract

A solasodine sulfate is prepared from black nightshade, kangroo apple, etc through extracting in acetic acid. It can be used to prepare the anticancer, anti-inflammatory and antiasthmatic medicines.

Description

technical field [0001] The invention relates to solanamine sulfate, a preparation method thereof and an application in medicine. Background technique [0002] At home and abroad, there are chemical components of Solanum solanum, Solanum solanum and Solanaceae chrysanthemum, detection methods of solanamine and anti-S 180 , anti-inflammation, blood sugar raising and other reports, but not yet found the Australian solanamine sulfate, the preparation method of Australian solanamine sulfate and the relevant information of the application of Australian solanamine sulfate in medicine. Contents of the invention [0003] The present invention provides an anti-cancer, anti-asthma and anti-inflammation drug with strong activity, long-term toxic and side effects, strong solubility, stable properties, simple and convenient production method, high purity and strong drug activity. The preparation method, and the application of this new...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61P11/06A61P29/00A61P35/00C07J71/00
Inventor 刘良刘芯辰崔淑华
Owner 刘良
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