Nano mesoporous and mesoporous-macroporous composite biological glass and its preparing method

A bioglass and nano-mesoporous technology, applied in medical science, prosthesis, etc., can solve the problems of macroporous bioglass materials that have not been reported, and achieve excellent biological activity, mild reaction conditions, and strong pore volume adsorption capacity.

Inactive Publication Date: 2004-12-15
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the preparation of uniform and controllable macroporous bioglass materials has not been reported

Method used

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  • Nano mesoporous and mesoporous-macroporous composite biological glass and its preparing method
  • Nano mesoporous and mesoporous-macroporous composite biological glass and its preparing method
  • Nano mesoporous and mesoporous-macroporous composite biological glass and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 2g P123+30g EtOH+1.04g Ca(NO 3 ) 2 4H 2 O+3.12gTEOS+0.18g TEP+0.5g0.5MHCl+0.5gPE was stirred at room temperature for 24h, aged at room temperature for 72h until a dry gel was formed, and baked in a box-type resistance furnace at 550°C for 24h, namely Nano-mesoporous and mesoporous-macroporous composite bioglasses were obtained.

Embodiment 2

[0033] 2g F127+30g EtOH+1.04g Ca(NO 3 ) 2 4H 2 O+3.12g TEOS+0.18g TEP+0.5g0.5MHClg+0.5g PBMA, stirred at room temperature for 48h, aged at room temperature for 72h until a dry gel was formed, and baked in a box-type resistance furnace at 700°C for 10h , that is, nano-mesoporous and mesoporous-macroporous composite bioglass.

Embodiment 3

[0035] 2g F108+30g EtOH+1.04g Ca(NO 3 ) 2 4H 2 O+3.12gTEOS+0.18g TEP+0.5g0.5MHCl was stirred at room temperature for 24h, then aged at room temperature for 48h until a dry gel was formed, and then baked at 600°C for 15h in a box-type resistance furnace to obtain nano-sized media. Hole Bioglass.

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Abstract

The present invention relates to nano mesoporous and mesoporous-macroporous biological glass produced and through surfactant self-assembling and sol-gel process under mild reaction condition and possessing excellent bioactivity. The new type of biological glass has controllable mesoporous structure, homogeneous and adjustable mesopore distribution, relatively great specific surface area and porosity, macropores with adjustable size and porosity, and controllable shape. The present invention may be used as bone repairing material, dental material and rack material in tissue engineering and for medicine embedding and controlling releasing, etc.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a nano-mesoporous and mesoporous-macroporous composite biological glass and a preparation method thereof. Background technique [0002] In the fields of biomaterials and medicine, bone defect repair has always been an important research topic. So far, people have studied a variety of bone defect repair materials, including artificial coral, animal bone, synthetic hydroxycarbonate, human tooth post-processing materials, and bioglass. Among them, biological glass is also a kind of artificial synthetic material, which is composed of silicon dioxide, calcium oxide, phosphorus pentoxide, and a small amount of Na 2 O, MgO, etc. This type of material has better osteogenic properties than hydroxycarbonated apatite, and also has superior biocompatibility and self-degradation properties. At present, bioglass has been certified by the US Food and Drug Administration (FDA...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10C03C1/00C03C3/06C03C3/097C03C4/00C03C11/00
CPCC03C1/006C03C11/00C03C4/0007
Inventor 余承忠严晓霞赵东元
Owner FUDAN UNIV
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