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Preparation method for ceramic agg egate of same kind and different structure

A kind of ceramization and similar technology, applied in the field of artificial biomaterials, can solve the problems that ceramized bone products have not yet been seen, and cannot fully meet the needs of clinical and tissue engineering bone research and application.

Inactive Publication Date: 2005-02-16
STOMATOLOGICAL HOSPITAL NO 4 ARMY MEDICAL COLLEGE PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its own structure, it can only be used as a packing material to treat small bone defects and construct a support for tissue-engineered bone that does not bear force, which cannot fully meet the needs of clinical and tissue-engineered bone research and application.
At present, there are no ceramic bone products with the above-mentioned excellent properties in the domestic market.

Method used

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  • Preparation method for ceramic agg egate of same kind and different structure
  • Preparation method for ceramic agg egate of same kind and different structure
  • Preparation method for ceramic agg egate of same kind and different structure

Examples

Experimental program
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Effect test

example 1

[0014] Example 1: Preparation of composite ceramic bone. Take fresh beef ribs, remove the muscles and fascia, cut the ribs longitudinally, and cross-cut them into bone pieces of different sizes; clean them, put them in 0.5mol / L sodium hydroxide solution for 14 hours, rinse them, and then put them in In 30% hydrogen peroxide for 12 hours, repeated treatment twice; then rinse with distilled water, then soak in 3:1 chloroform-alcohol mixture and acetone for 1 hour each for dehydration; then soak in ethanol for 4 hours After drying, put it in a muffle furnace for calcination at 900°C for 1 hour. After cooling, take out the composite ceramic bone and store it in a sterile container.

example 2

[0015] Example 2: Preparation of cancellous bone ceramic bone. The epiphysis of the femur was removed and cut into cancellous bone pieces of different sizes; cleaned, placed in 0.5mol / L sodium hydroxide solution for 12 hours, rinsed, and then placed in 30% hydrogen peroxide for 16 hours, Repeat the treatment twice; then rinse with distilled water, bake in an oven at 42°C for 48 hours; place in a muffle furnace for calcination at 700°C for 4 hours, take out the cancellous bone ceramic bone and put it in a sterile container after cooling save.

example 3

[0016] Example 3: Preparation of cortical bone ceramic bone. Cut the femoral shaft longitudinally, cut it into pieces, and clean it; put it in 0.5mol / L sodium hydroxide solution for 16 hours, rinse it, then put it in 30% hydrogen peroxide for 12 hours, and repeat the treatment twice; rinse it clean After soaking in ethanol for 6 hours, dry it; then place it in a muffle furnace and calcine it at 800°C for 3 hours. After cooling, take out the cortical bone-type ceramic bone and store it in a sterile container.

[0017] Granular ceramic bone is obtained by grinding and sieving any one of the above three types.

[0018] The clinical application principle of the present invention and the principle of constructing tissue engineered bone are explained as follows: Since the ceramic bone of the present invention is a group of biomaterials with different structures, it is suitable for clinical diseases such as different bone defects and nonunions, and long bone defects can be cortical b...

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Abstract

The invention relates to a group of medical ceramic bone with different structures in the same class. The inorganic crystal grid is consistent to the normal bone with the method, it can be divided into skin bone type, loose bone type, compound type and particle type according to the structures, its primary ingredient is natural ramification of aspatite. The manufacturing method is: selects bones on different part of huge animal, and then carries on degreasing, protein eliminating, dehydrating, and baking. According to different structures, the carrier which can be used as transplanting material, medicine or growing factor and bracket material of organization project, it can form new bones with different effects.

Description

technical field [0001] The invention belongs to the technical field of artificial biomaterials in tissue engineering, and relates to a preparation method of a group of similar ceramic bones with different structures. Background technique [0002] Tissue Engineering, which was born in the early 1990s, is a discipline that utilizes the principles of engineering and life sciences to integrate isolated cells or recruit cells in the local environment of receptors with artificial synthetic materials to form new and effective tissues. Emerging frontier science of functional organization. Its establishment and development depend on the progress of tissue culture, biomaterial science and organ transplantation. Due to the special mechanical requirements of bone tissue, materials with certain mechanical properties such as inorganic salts, synthetic polymers and natural polymers are mostly used as scaffold materials. Ceramic bone is a group of naturally derived inorganic materials tha...

Claims

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Application Information

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IPC IPC(8): A61L27/36
Inventor 金岩何大为
Owner STOMATOLOGICAL HOSPITAL NO 4 ARMY MEDICAL COLLEGE PLA
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