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Composition of cupresulflavone and its preparation

A technology of dried cedar and total flavonoids is applied in the direction of drug combination, pharmaceutical formulation, drug delivery, etc., to achieve the effects of exact drug effect, high yield and clear composition

Inactive Publication Date: 2005-02-23
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its use as a medicine and its chemical composition have not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 60kg of the above-ground part of dried cedar, crush it into coarse powder, and put it into an extraction tank; add 360L of water to reflux and extract 3 times, each time for 2 hours; Filter out the precipitate; pass the filtrate through a HP-20 macroporous adsorption resin column, add deionized water to elute until the effluent is clear and neutral; add 50% ethanol to wash the column, collect the eluate and concentrate, add 60L of water to dissolve, Filtrate; add 30L n-butanol to the filtrate and extract 3 times respectively, combine the alcoholic solution; concentrate the alcoholic solution to dryness under reduced pressure according to conventional vacuum, and dry to obtain 1.0 kg of yellow dry cedar flavonoid raw material.

[0018] Measured by high-performance liquid chromatography: the total flavonoid content in the dry cedar flavonoid raw material obtained in the above experiment is 59%, and the main anti-tumor component catechin content in the raw material is ...

Embodiment 2

[0020] Get 150kg of branches and leaves of dry cedar, crush them into 2-3cm sections, put them into an extraction tank; add 900L of water to reflux and extract 3 times, each time for 2 hours; add sodium hydroxide solution to the extract to adjust the pH to 9.0, Stand still; filter out the precipitate; pass the filtrate through a HD-2025 macroporous adsorption resin column, add deionized water to elute until the effluent is clear and neutral; add 75% ethanol to wash the column, collect the eluate and concentrate, add water 75L was dissolved and filtered. The filtrate was added to 75L n-butanol for extraction three times, and the alcohol solutions were combined. The alcoholic solution was concentrated under reduced pressure to dryness, and dried to obtain 1.8 kg of yellow dry cedar flavone powder.

[0021] As determined by high-performance liquid chromatography: the total flavonoid content in the dry cedar flavonoid powder raw material is 55%, and the main anti-tumor component ...

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PUM

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Abstract

A Ganxiang cypress' flavone composition used for preparing the medicine to treat tumor is prepared from the twigs and leaves of Ganxiang cypress through extracting in water, regulating pH-9-10, macroreticular resin adsorbing, eluting, extracting by butanol and concentrating.

Description

1. Technical field: [0001] The invention belongs to the technical field of preparation methods of natural medicines, and in particular relates to an antitumor flavonoid composition in dried cedar branches and leaves and a preparation method thereof. 2. Background technology: [0002] Dried cedar, a plant of the Cupressaceae family, is a timber tree species used in my country. It has a hard material, a fine structure, and a fragrance. It can be used for construction, papermaking, utensils, and furniture. Distributed in Yunnan, Sichuan and other provinces as afforestation tree species for windbreak, sand fixation and water and soil conservation. Its use as a medicine and its chemical composition have not been reported. [0003] There are many species of Cupressaceae in my country, about 20 of which are used for medicinal purposes. Its branches, leaves and heartwood generally contain ingredients such as volatile oil, flavonoids, lignans, anthraquinones and terpenes. The cypre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/14A61K9/20A61K9/48A61K31/7048A61P35/00
Inventor 刘志礼谭宁华许剑锋
Owner NANJING UNIV