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Medicinal composition containing salvianolic acid B, total ara-saponin and camphol and its preparation and use

A technology of Panax notoginseng saponins and salvianolic acid, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas. low effect

Active Publication Date: 2005-03-02
广东天之骄生命科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention adopts the method of ultrasonic extraction, ultrafiltration, ethyl acetate extraction, rotary scraping film concentration technology to extract the active ingredient mainly salvianolic acid B from Salvia miltiorrhiza; adopts water extraction and alcohol precipitation method, macroporous resin adsorption method Extract and purify the active ingredients of Panax notoginseng total saponins; use hydroxypropyl β-cyclodextrin (HP-β-CD) to include borneol in the prescription, which solves its difficulty in dissolving in aqueous injection solutions improve the quality and clinical efficacy of preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] (1) The prescription of the API is: Salvia miltiorrhiza 500g, borneol 10g, Panax notoginseng 160g;

[0091] (2) Take the decoction pieces of Salvia miltiorrhiza, pulverize, add 10 times of water, put it into an ultrasonic extraction tank, and perform ultrasonic vibration extraction, the time is 50 minutes, the oscillation frequency is 100 kHz, and the temperature is controlled to be room temperature, extract 4 times, and combine the extracts Filtration, the filtrate was centrifuged at 13000rpm, the centrifuge was ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 5,000, and the filtrate was concentrated to a relative density of 1.15 with a rotary scraping film concentrator controlled at a temperature of 40°C. Extract 9 times of ethyl acetate with 9 times of ethyl acetate, combine the ethyl acetate liquid, use a rotary wiped film concentrator with a controlled temperature of 40 ° C to concentrate, and the extract obtained by concentration is...

Embodiment 2

[0097] (1) The prescription of the API is: Salvia miltiorrhiza 400g, borneol 6g, Panax notoginseng 120g;

[0098] (2) Take the pieces of Danshen medicinal materials, pulverize them, add 6 times of water, put them into an ultrasonic extraction tank, perform ultrasonic vibration extraction, the time is 20 minutes, the oscillation frequency is 20 kHz, the temperature is controlled to be room temperature, the extraction is performed twice, and the extracts are combined. Filtration, the filtrate was centrifuged at 12000rpm, the centrifuge was ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 5000, and the filtrate was concentrated to a relative density of 1.10 with a rotary scraping membrane concentrator controlled at a temperature of 40 °C. Extract 3 times of ethyl acetate with twice as much ethyl acetate, combine the ethyl acetate solutions, and concentrate with a rotary wiper concentrator whose temperature is controlled at 40 °C. of salvia extract...

Embodiment 3

[0104] (1) The prescription of the API is: Salvia miltiorrhiza 450g, borneol 8g, Panax notoginseng 141g;

[0105] (2) Take the decoction pieces of Salvia miltiorrhiza, pulverize, add 8 times of water, put it into an ultrasonic extraction tank, and perform ultrasonic vibration extraction, the time is 40 minutes, the oscillation frequency is 50 kHz, and the temperature is controlled to be room temperature, extract 3 times, and combine the extracts Filtration, centrifugation of the filtrate at 18,000 rpm, ultrafiltration of the centrifuge with an ultrafiltration membrane with a molecular weight cut-off of 5,000, and concentration of the filtrate to a relative density of 1.13 with a rotating scraped membrane concentrator controlled at a temperature of 40 °C. 5 times of ethyl acetate, combined with ethyl acetate, concentrated with a rotary wiper concentrator controlled at a temperature of 40°C, and the concentrated extract was vacuum-dried below 40°C to obtain salvianolic acid B as ...

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Abstract

The medicinal composition of the present invention is compound freeze dried red sage powder for injection comprising red sage extract with salvianolic acid as main component, notoginseng extract with arasaponin as main component, hydroxypropyl beta-cyclodextrin clathrate of borneol and medicinal supplementary material. The preparation process includes extracting red sage component via ultrasonic extraction, ultrafiltering, ethyl acetate extraction and concentration; extracting notoginseng component via water extraction, alcohol precipitation and macro resin adsorption; clathrating borneol to raise its water solubility; and other steps. The present invention is used in preventing and treating cardiac and cerebral vascular diseases and has obvious curative effect.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a pharmaceutical combination group containing salvianolic acid B, Panax notoginseng saponins and borneol, and preparation and application thereof. This pharmaceutical composition is also called compound salvia lyophilized powder for injection. Background technique [0002] Coronary heart disease and angina pectoris are clinically common and frequently-occurring diseases. In recent years, with the improvement of people's living standards, the age of onset of coronary heart disease has advanced. The development of drugs for the treatment of cardiovascular and cerebrovascular diseases has gradually become a research hotspot. More and more clinical reports show that traditional Chinese medicine has a good application prospect in the treatment of coronary heart disease and angina pectoris. The compound Danshen preparation composed of Danshen...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P9/10
Inventor 张正生
Owner 广东天之骄生命科技有限公司
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