Colon positioning and adhering preparation and its preparing process

Abstract

Disclosed is a colon positioning and adhering preparation and its preparing process which comprises mixing Metronidazole, starch, dextrin and bletilla striata, charging starch grout and preparing particles, obtaining wet micro-pullet, drying, pressing into tablet, mixing dressing material, ethanol, castor-oil, dibutyl phthalate into dressing liquid, preparing dressed micro-pullet or dressed tablet, and loading the dressed micro-pullet into capsule or directly split charging into micro-pullet pills.

Description

technical field

[0001] The invention relates to a colonic adhesion pharmaceutical preparation and a preparation method thereof, in particular to a colon localized adhesion preparation and a preparation method thereof. Background technique

[0002] Because of its special physiological environment, the colon is particularly suitable as a target organ for some special diseases and drug treatments. In recent years, the colon-targeted drug delivery system has made great progress in the research of formulations and localized materials, some of which have been used clinically and become commercial products, showing promising prospects. Colon-targeted drug delivery is of great significance to the treatment of intestinal diseases such as constipation, colitis, and colorectal cancer, as well as the oral delivery of protein and polypeptide drugs, and it is a promising new research field. This drug delivery system has developed into a pH-dependent type in just over ten years (Fu Chongd...