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Colon positioning and adhering preparation and its preparing process

A colon positioning and preparation technology, which is applied in the directions of pill delivery, pharmaceutical formulations, and non-active ingredients medical preparations, etc., can solve the problems of reducing swelling degree and poor positioning of polymer materials, improving compliance, inhibiting growth, reducing Effects of adverse reactions

Inactive Publication Date: 2005-03-16
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the positioning of the first two dosage forms after administration is poor
Now the most promising flora-triggered drug delivery system, the key problem is how to improve the hydrophobicity of polymer materials and reduce the swelling degree

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1: first 8 parts of metronidazole, 40 parts of starch, 17 parts of dextrin and 35 parts of bletilla striata gum are mixed uniformly; then adding 30 parts of mass concentration is 10% starch slurry and stirred evenly to make soft material, wet granules were prepared; the wet granules were added into the coating pan and rolled for 5 hours to obtain wet pellets; the wet pellets were dried at 40°C for 4 hours to obtain dry pellets; 12 parts of the coated Coating material polyacrylic acid resin and 100 parts of mass concentration are 95% ethanol and 28 parts by the mass ratio of 1: 1 mixed castor oil, dibutyl phthalate are mixed to make coating liquid; Coating liquid coating rolls 4 hours to the weight of dry pellet and increases 20% to make coated pellet; This coated pellet is packed into capsule, and the filling amount of every capsule is 0.2 gram and gets final product. The obtained capsule contains 8 parts of metronidazole, 40 parts of starch, 17 parts of dext...

Embodiment 2

[0008] Embodiment 2: first 10 parts of metronidazole, 42 parts of starch, 15 parts of dextrin and 33 parts of bletilla striata gum are mixed uniformly; then adding 15 parts of mass concentration is 10% starch slurry and stirred evenly to make soft material, to make wet granules; put the prepared wet granules into the coating pan and roll for 6 hours to make wet pellets; dry the wet pellets at 60°C for 3 hours to make dry pellets; put 18 parts of the coated The coating material CAP is mixed with 100 parts of mass concentration of 95% ethanol and 10 parts of castor oil and dibutyl phthalate mixed in a mass ratio of 1:1 to make a coating solution; The liquid coating was rolled for 5 hours until the weight of the dried pellets increased by 10% to make coated pellets; the coated pellets were packed into capsules, and the filling amount of each capsule was 0.4 g. The obtained capsule contains 10 parts of metronidazole, 42 parts of starch, 15 parts of dextrin and 33 parts of bletilla...

Embodiment 3

[0009] Embodiment 3: first 9 parts of metronidazole, 50 parts of starch, 13 parts of dextrin and 28 parts of bletilla striata gum are mixed uniformly; then adding 28 parts of mass concentration is 10% starch slurry and stirs to make soft material, wet granules were prepared; the prepared wet granules were added into the coating pan and rolled for 5.6 hours to obtain wet pellets; the wet pellets were dried at 50°C for 1 hour to obtain dry pellets; 25 parts of the coated Coating material shellac and 100 parts of mass concentration are 95% ethanol and 19 parts castor oil mixed by 1: 1 mass ratio, dibutyl phthalate are mixed to make coating liquid; The coating solution was coated and rolled for 4.5 hours until the weight of the dried pellets increased by 15% to make coated pellets; the coated pellets were directly packed into 0.2 g pellets. The obtained pellet preparation contains 9 parts of metronidazole, 50 parts of starch, 13 parts of dextrin and 28 parts of bletilla striata gu...

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Abstract

Disclosed is a colon positioning and adhering preparation and its preparing process which comprises mixing Metronidazole, starch, dextrin and bletilla striata, charging starch grout and preparing particles, obtaining wet micro-pullet, drying, pressing into tablet, mixing dressing material, ethanol, castor-oil, dibutyl phthalate into dressing liquid, preparing dressed micro-pullet or dressed tablet, and loading the dressed micro-pullet into capsule or directly split charging into micro-pullet pills.

Description

technical field [0001] The invention relates to a colonic adhesion pharmaceutical preparation and a preparation method thereof, in particular to a colon localized adhesion preparation and a preparation method thereof. Background technique [0002] Because of its special physiological environment, the colon is particularly suitable as a target organ for some special diseases and drug treatments. In recent years, the colon-targeted drug delivery system has made great progress in the research of formulations and localized materials, some of which have been used clinically and become commercial products, showing promising prospects. Colon-targeted drug delivery is of great significance to the treatment of intestinal diseases such as constipation, colitis, and colorectal cancer, as well as the oral delivery of protein and polypeptide drugs, and it is a promising new research field. This drug delivery system has developed into a pH-dependent type in just over ten years (Fu Chongd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/48A61K31/4164A61K47/36A61K47/40A61K47/46A61P1/00A61P1/10A61P35/00
Inventor 王兰杨芳巨杭生陈合
Owner SHAANXI UNIV OF SCI & TECH
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