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Orally disintegrating tablet of antiviral medicine and its preparation process

An orally disintegrating tablet and antiviral technology, applied in antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of long heating time of volatile active ingredients, increasing the economic burden of patients, increasing production costs, etc. problem, to achieve the effect of short extraction time, improved efficacy and increased stability

Inactive Publication Date: 2005-03-16
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process has the following disadvantages: when extracting by steam distillation, the volatile active ingredients are heated for a long time and are easy to deteriorate, and the extraction efficiency is low. Ineffective components of starch, mucus, protein, resin, etc.
Therefore, the orally disintegrating tablets made of these excipients have relatively strict environmental requirements during production, storage and transportation, and special packaging, sealing caps, desiccant bags, etc. must be used, which will have a great impact on production costs.
Moreover, the above-mentioned disintegrants are all synthesized through a chemical process, and the price is relatively high. For orally disintegrating tablets with a relatively large content of excipients, it will lead to increased production costs and further increase the economic burden on patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0147] (1) The weight of raw medicinal materials is:

[0148] Banlangen 30g Gypsum 20g Reed Root 15g

[0149] Habitat 12g, Turmeric 7g, Anemarrhena 9g

[0150] Shichangpu 5g Forsythia 11g Patchouli 7g

[0151] (2) Take turmeric, calamus, forsythia, patchouli medicinal materials, pulverize, pass through a 40-mesh sieve, undergo supercritical extraction, the extraction pressure is 15Mpa, and extract 2 hours at 30° C. to obtain 0.42 g of supercritical extract The dregs are ready for use; the supercritical extract is slowly added to the HP-β-CD aqueous solution, stirred at 50°C for 3 hours, continued to stir at room temperature for 5 hours, and filtered to obtain 3.4g of clathrate;

[0152] (3) Mix the above-mentioned dregs with Radix Radix Radix and Anemarrhena, and extract twice with 85% ethanol; each time add a solvent equivalent to 8 times the weight of the medicinal material; extract for the first time for 2 hours, and extract for the second time for 2 hours; combine Ethan...

Embodiment 2

[0162] (1) The weight of raw medicinal materials is:

[0163] Banlangen 35g, gypsum 14g, reed root 15g

[0164] Habitat 8g Turmeric 6g Anemarrhena 8g

[0165] Shichangpu 6g Forsythia 12g Patchouli 6g

[0166] (2) Take turmeric, calamus, forsythia, patchouli medicinal materials, pulverize, pass through a 30-mesh sieve, undergo supercritical extraction, the extraction pressure is 36Mpa, and extract 3 hours at 65° C. to obtain 0.88 g of supercritical extract The dregs are ready for use; the supercritical extract is slowly added to the β-CD aqueous solution, stirred at 50°C for 3 hours, continued to stir at room temperature for 5 hours, and filtered to obtain 7.42g of clathrate;

[0167] (3) Mix the above-mentioned medicinal residues with Radix Radix Radix and Anemarrhena, extract twice with 70% ethanol; each time add a solvent equivalent to 10 times the weight of the medicinal material; extract for the first time for 1 hour, and extract for the second time for 2 hours; combine ...

Embodiment 3

[0177] (1) The weight of raw medicinal materials is:

[0178] Banlangen 36g, gypsum 16g, reed root 17g

[0179] Habitat 9g Turmeric 7g Anemarrhena 7g

[0180] Shichangpu 7g Forsythia 13g Patchouli 8g

[0181] (2) Take turmeric, calamus, forsythia, and patchouli medicinal materials, pulverize them, pass through a 30-mesh sieve, undergo supercritical extraction, the extraction pressure is 48Mpa, and extract 2 hours at 27°C for 2 hours to obtain 1.27g of supercritical extract The dregs are used for later use; the supercritical extract is slowly added to the HP-β-CD aqueous solution, stirred at 50°C for 3 hours, continued to stir at room temperature for 5 hours, and filtered to obtain 10.6g of clathrate;

[0182] (3) Mix the above-mentioned medicinal residues with Radix Radix Radix and Anemarrhena, and extract twice with 65% ethanol; each time add a solvent equivalent to 6 times the weight of the medicinal material; extract for the first time for 3 hours, and extract for the sec...

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PUM

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Abstract

The invention discloses an antiviral orally disintegrating tablet comprising, the cyclodextrin inclusion compound of hypercritical extract of curcuma aromatica, grassleaved sweetflag rhizome, capsule of weeping forsythia, patchouli, their dross and extracts of isatic root, anemarrhena rhizome, dried rehmannia root, and medicinal findings. The invention also discloses its preparation, and a composite disintegration agent used for the orally disintegrating tablet, which comprises 30%-70% of tetrahydroxy butane and chitosan or the conventional disintegration agents.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to an antiviral orally disintegrating tablet and a preparation method thereof. technical background [0002] Antiviral Oral Solution (WS 3 -49(X-39)-92(Z)) and antiviral thrombus (WS 3 -B-2150-96) is made from isatis root, gypsum, reed root, habitat, turmeric, anemarrhena, calamus, forsythia and patchouli. The extraction process of the two is: forsythia, turmeric, calamus, and patchouli are used to extract the volatile oil by steam distillation; the dregs are then extracted with five herbs such as Radix Radix and other five herbs to obtain the extract by water extraction and alcohol precipitation. This process has the following disadvantages: when extracting by steam distillation, the volatile active ingredients are heated for a long time and are easy to deteriorate, and the extraction efficiency is low. Ineffective ingredients such as starch, muc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P31/12
Inventor 张晴龙
Owner 张晴龙
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