Production method of enzymolysis forest frog oil and softcapsule

A technology of wood frog oil and enzymatic hydrolysis, which can be used in capsule delivery, medical preparations containing active ingredients, pharmaceutical formulas, etc., and can solve the problems of delamination and poor absorption.

Inactive Publication Date: 2005-03-23
李津明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to poor absorption by the human body, the prepared soft capsules have serious stratification in their contents.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0004] Specific embodiment 1: The enzymatic hydrolysis of Rana sylvatica oil in this embodiment is achieved by the following steps: 1. Soak Rana sylvatica oil in distilled water for 16-20 hours and take it out. After removing the fascia and impurities, it is heated in an electric heating mantle. After 95~100℃, immediately pour it into a beater for beating, take it out after being beaten, and keep it in a refrigerator for later use; under normal circumstances, natural proteins can resist the hydrolysis of proteolytic enzymes, mainly due to sensitive residues. It is often hidden in the interior of the molecule, or due to the folding of the peptide chain, the side chain interaction between them, which affects the proximity of the enzyme molecule and sensitive amino acid residues. Therefore, the purpose of heating and beating is to quickly destroy and deform the spatial structure of the protein, so that the peptide chain can be scattered for enzymatic hydrolysis. 2. Make the evenly be...

specific Embodiment approach 2

[0005] Specific embodiment 2: The enzymatic hydrolysis of Rana chensinensis oil in this embodiment is realized by the following steps: 1. Soak Rana chensinensis oil in distilled water for 18 hours and take it out. After removing fascia impurities, it is placed in an electric heating mantle and heated to 100°C. Immediately pour it into the beater to beat, take it out after being beaten, and store it in a refrigerator for later use; 2. Make an aqueous suspension of the beaten forest frog oil and water at a weight ratio of 1:40, and mix it in water Papain was added to the suspension, the amount of papain added was 0.4% of the weight of Rana temporaria oil in the water suspension, and it was hydrolyzed for 3 hours in an electric thermostatic water bath at a temperature of 60°C and a pH of 7; 3. , Add pepsin to the Rana chensinensis oil enzymatic hydrolysate with papain. The amount of pepsin added is 0.3% of the weight of Rana chensinensis oil in the water suspension. In an electric th...

Embodiment approach 1

[0006] The first embodiment is the same.

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PUM

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Abstract

A softcapsule of enzymolyzed tree frog fat is prepared through homogenizing tree frog fat, proportionally mixing it with water, adding papain and pepsin, enzymolyzing, freeze drying, superfine pulverizing, proportionally mixing with the mixture of soybean phosphatide, colloid grinding, and die pressing.

Description

Technical field: [0001] The invention relates to the enzymatic hydrolysis of forest frog oil and the production process of soft capsules. Background technique: [0002] Rana temporaria oil (Oviductus Ranae) is the dry fallopian tube of Chinese female Rana temporaria (Rana temporaria chensinesis Darid). The main components of forest frog oil are protein and fat-soluble components. Such as steroid hormones and so on. It is a kind of famous Chinese and foreign rare therapeutic Chinese medicine that is a specialty of Northeast my country, and it is known as "soft gold" in the international market. It has the effects of nourishing the kidney and essence, nourishing yin and moisturizing the lung. At present, most of the wood frog oil products on the market are dry products, which need to be processed when taken, which is troublesome and very inconvenient. The main component of wood frog oil is protein, which accounts for about 60% of the quality of wood frog oil. The amino acid is cont...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K35/65A61P3/02
Inventor 李津明
Owner 李津明
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