Application of levocarnitine and its derivative in preventing and treating high altitude diseases

A derivative, high-altitude sickness technology, applied in the field of prevention and treatment of high-altitude sickness, to achieve the effect of promoting economic development, broadening the scope of application, and expanding the living space of human beings

Active Publication Date: 2005-04-27
NORTHEAST PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above drugs obviously do n

Method used

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  • Application of levocarnitine and its derivative in preventing and treating high altitude diseases
  • Application of levocarnitine and its derivative in preventing and treating high altitude diseases

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0029] Example one

[0030] Levocarnitine tablets were prepared according to the following formula (contents used are percentages by weight)

[0031] L-carnitine tartrate 50%

[0032] Lactose 25%

[0033] Starch 24%

[0034] Stearic acid 1%

[0035] (1) Crush the L-carnitine tartrate and lactose separately, pass a 100-mesh sieve, and pass the starch directly through a 100-mesh sieve for later use;

[0036] (2) Prepare a 10% starch paste with an appropriate amount of starch for use as a binder;

[0037] (3) Mix Levocarnitine, lactose and the remaining amount of starch, add a binder to make a softener, and pass through a 16-mesh sieve to make granules;

[0038] (4) Place the wet granules in a drying box at about 50°C and blast dry for about 3 hours;

[0039] (5) After the dry granules are sized through a 16-mesh sieve, add magnesium stearate and mix well;

[0040] (6) Take a flat punch with a diameter of 90mm to get it.

Example Embodiment

[0041] Example two

[0042] L-carnitine tartrate capsules were prepared according to the following formula (contents used are percentages by weight)

[0043] Levocarnitine stearate 90%

[0044] Starch 10%

[0045] (1) Pass the L-carnitine tartrate and starch through a 100-mesh sieve respectively for pretreatment;

[0046] (2) Mix the processed L-carnitine tartrate and starch thoroughly;

[0047] (3) Fill the mixed powder into the No. 2 empty capsule to get it.

Example Embodiment

[0048] Example three

[0049] Prepare Levocarnitine oral liquid according to the following formula (contents used are percentages by weight)

[0050] L-carnitine internal salt 5%

[0051] Stabilizer 94%

[0052] Citric acid 1%

[0053] Preservative

[0054] Add distilled water and divide into 5g / 100ml.

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Abstract

The present invention relates to new medicinal application of levocarnitine as one kind of known compound and its derivative. Levocarnitine or its derivative is used as active component combined with one or several excipients and prepared via conventional process into tablet, capsule, oral liquid, injection, etc. for preventing and assisting treatment of high altitude diseases. The present invention is superior to available hormone medicine and diuretic medicine, which result in side effects, and hyperbaric oxygen therapy, which is inconvenient and has relatively low safety.

Description

(1) Technical field [0001] The present invention relates to the new application of levocamitine (Levocamitine) and its derivatives, in particular to the application in preventing and treating altitude sickness. (2) Background technology [0002] Altitude sickness refers to a kind of symptoms related to low air pressure when people enter the area above 3000 meters above sea level for a short time, such as headache, nausea, fatigue, anorexia, etc. In severe cases, high altitude pulmonary edema, cerebral edema, heart failure, etc. Serious event, if these symptoms are not treated in time, it will lead to death. The incidence of altitude sickness is high, and 35-80% of the people who fly to the Qinghai-Tibet Plateau suffer from different degrees of acute altitude sickness. [0003] The main cause of altitude sickness is low air pressure and low oxygen partial pressure, which lead to hypoxia in the human body, which prevents the energy-producing substances in the body from effect...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/10A61K9/20A61K9/48A61K31/221A61P43/00
Inventor 韩俊艳
Owner NORTHEAST PHARMA GRP
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