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Application of levocarnitine and its derivative in preventing and treating high altitude diseases

A derivative, high-altitude sickness technology, applied in the field of prevention and treatment of high-altitude sickness, to achieve the effect of promoting economic development, broadening the scope of application, and expanding the living space of human beings

Active Publication Date: 2005-04-27
NORTHEAST PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above drugs obviously do not fully meet these conditions

Method used

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  • Application of levocarnitine and its derivative in preventing and treating high altitude diseases
  • Application of levocarnitine and its derivative in preventing and treating high altitude diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Prepared levocarnitine tablet according to the following formula (all contents used are weight percentages)

[0031] L-Carnitine Tartrate 50%

[0032] Lactose 25%

[0033] Starch 24%

[0034] Stearic acid 1%

[0035] (1) Pulverize levocarnitine tartrate and lactose respectively, pass through a 100-mesh sieve, and directly pass the starch through a 100-mesh sieve for subsequent use;

[0036] (2) Take an appropriate amount of starch to prepare 10% starch paste for use as a binder;

[0037] (3) Mix levocarnitine, lactose and the remaining amount of starch, add a binder to make soft powder, pass through a 16-mesh sieve to make granules;

[0038] (4) Place the wet granules in a drying oven at about 50°C, and dry them by air for about 3 hours;

[0039] (5) After the dry granules are sized through a 16-mesh sieve, magnesium stearate is added and mixed uniformly;

[0040] (6) Punch and press the tablet with a diameter of 90 mm.

Embodiment 2

[0042] L-carnitine tartrate capsules were made according to the following formula (all contents used are weight percentages)

[0043] L-Carnitine Tartrate 90%

[0044] Starch 10%

[0045] (1) L-carnitine tartrate and starch are respectively passed through a 100 mesh sieve for pretreatment;

[0046] (2) Fully mix the processed L-carnitine tartrate and starch;

[0047] (3) Fill the mixed medicinal powder into No. 2 empty capsules.

Embodiment 3

[0049] Levocarnitine oral liquid was obtained according to the following formula (all contents used are weight percentages)

[0050] L-Carnitine Inner Salt 5%

[0051] Stabilizer 94%

[0052] Citric acid 1%

[0053] Appropriate amount of preservatives

[0054] Add distilled water, aliquot into 5g / 100ml.

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Abstract

The present invention relates to new medicinal application of levocarnitine as one kind of known compound and its derivative. Levocarnitine or its derivative is used as active component combined with one or several excipients and prepared via conventional process into tablet, capsule, oral liquid, injection, etc. for preventing and assisting treatment of high altitude diseases. The present invention is superior to available hormone medicine and diuretic medicine, which result in side effects, and hyperbaric oxygen therapy, which is inconvenient and has relatively low safety.

Description

(1) Technical field [0001] The present invention relates to the new application of levocamitine (Levocamitine) and its derivatives, in particular to the application in preventing and treating altitude sickness. (2) Background technology [0002] Altitude sickness refers to a kind of symptoms related to low air pressure when people enter the area above 3000 meters above sea level for a short time, such as headache, nausea, fatigue, anorexia, etc. In severe cases, high altitude pulmonary edema, cerebral edema, heart failure, etc. Serious event, if these symptoms are not treated in time, it will lead to death. The incidence of altitude sickness is high, and 35-80% of the people who fly to the Qinghai-Tibet Plateau suffer from different degrees of acute altitude sickness. [0003] The main cause of altitude sickness is low air pressure and low oxygen partial pressure, which lead to hypoxia in the human body, which prevents the energy-producing substances in the body from effect...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/10A61K9/20A61K9/48A61K31/221A61P43/00
Inventor 韩俊艳
Owner NORTHEAST PHARMA GRP
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