Temozolomide-polymer local slow release chemotherapy medicine for treating malignant brain tumor

A malignant brain tumor, temozolomide technology, applied in the medical field, can solve the problem of short residence time of brain tumor tissue

Inactive Publication Date: 2005-05-18
赵世光 +1
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  • Summary
  • Abstract
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  • Application Information

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Problems solved by technology

Oral absorption of temozolomide can pass through the blood-brain barrier and enter the cerebrospinal fluid, but it has been reported in the literature that its drug concentration in the cerebrospinal fluid is only 30-40% of the plasma, and the brain tumor tissue has a short residence time, causing side effects such as bone marrow suppression and gastrointestinal reactions.

Method used

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Embodiment Construction

[0008] The present invention is composed of temozolomide and macromolecular biodegradable polymer material, adopts the composite method of polymer medicament, and makes tablets with different thicknesses and shapes through molding or casting technology, and each tablet contains temozolomide to control the biological characteristics of different tumors. In the range of 5-20mg, it is sterilized by γ-ray irradiation after it is made.

[0009] The invention integrates the temozolomide with anti-tumor effect into the degradable polymer macromolecule, and releases the drug slowly, continuously and stably through the erosion and hydrolysis of the polymer and exerts its effect. High molecular polymers are biodegradable materials, and their own metabolites are non-toxic, and have the advantages of high drug loading rate, good biocompatibility and small antigenicity. There are many kinds of biodegradable polymer materials that can be selected: such as polylactic acid (PLA), polyglycolic...

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Abstract

The present invention discloses a slow release system of Temozolomide as local slow release medicine and biodegraded polymer for treating malignant brain tumor, and the slow release system is implanted into operated area of excising malignant brain tumor for local slow release treatment of malignant brain tumor and prolonging the survival period of the patient. The present invention consists of Temozolomide and biodegraded polymer material in the weight ratio of 1.5 to 10. Temozolomide is fused into biodegraded polymer, and through the corrosion of the polymer and hydrolysis of the polymer, the medicine is released slowly, continuously and stably to act. The polymer is PLA, PGA, PLGA, PFAD-SA and/or the copolymer of p-carboxyl phenoxyl propane and sebasic acid.

Description

Technical field: [0001] The invention belongs to a local slow-release drug, in particular to a local slow-release chemotherapeutic drug for treating malignant brain tumors. The invention is a new dosage form of the chemotherapeutic drug temozolomide except the oral dosage form, which broadens its application range and belongs to the field of medical technology. technical background: [0002] Temozolomide is a new type of chemotherapy drug for oral treatment of glioma. It belongs to imidazolium tetrazine derivatives. It was approved for marketing by the European Union and the United States in 1999. It is a second-line drug for glioblastoma such as astrocytoma, and the approved indications in EU countries are glioblastoma multiforme that still develops or recurs after conventional treatment. Glioma accounts for the first place in central nervous system tumors and is one of the refractory diseases in neurosurgery. Due to the infiltrative growth of glioma and the unclear bound...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/4188A61P35/00
Inventor 赵世光张健
Owner 赵世光
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