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Palonosetron injection and its powder injection preparation of salt receptable on medicine and its preparing method

A technology for injection and medicine, which is applied in the field of powder injection preparation of palonosetron for injection and its pharmaceutically acceptable salt and its preparation, and can solve the problem of poor pH value, light stability and clinical medication safety of aqueous injection preparations and effectiveness effects, etc., to achieve the effect of easy storage, improved stability, and not easy to oxidize

Active Publication Date: 2005-05-18
杭州容立医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are water injection preparations on the market, which have a very good curative effect on the treatment of vomiting caused by chemotherapy in clinical practice, but the pH value and photostability of the water injection preparations are relatively poor, thus causing problems for the safety and effectiveness of clinical medication. certain influence

Method used

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  • Palonosetron injection and its powder injection preparation of salt receptable on medicine and its preparing method
  • Palonosetron injection and its powder injection preparation of salt receptable on medicine and its preparing method
  • Palonosetron injection and its powder injection preparation of salt receptable on medicine and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] Example 1: Palonosetron Powder Injection Prescription

[0089] Palonosetron 0.25g,

[0090] Mannitol 230g,

[0091] Sodium dihydrogen phosphate 40g,

[0092] Add water for injection to 3000ml, and make 1000 sticks in total.

Embodiment 2

[0093] Example 2: Palonosetron Powder Injection Prescription

[0094] Palonosetron 0.25g,

[0095] Mannitol 240g,

[0096] Ascorbic acid 12g,

[0097] Add water for injection to 2000ml, and make 1000 sticks in total.

Embodiment 3

[0098] Example 3: Prescription of Palonosetron Hydrochloride Powder Injection

[0099] Palonosetron hydrochloride (calculated as palonosetron) 0.25g,

[0100] Mannitol 250g,

[0101] Add water for injection to 800ml, and make 1000 sticks in total.

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Abstract

The present invention relates to palonosetron as medicine for treating chemotherapy caused vomiting and its pharmaceutically acceptable salt, and is especially medicine powder of palonosetron and its pharmaceutically acceptable salt for injection and its preparation process. The medicine powder for injection consists of palonosetron and its pharmaceutically acceptable salt and excipient, and may have also pH regulator, antioxidant and other supplementary material.

Description

technical field [0001] The invention relates to a medicine palonosetron (palonosetron) and its pharmaceutically acceptable salt for treating vomiting caused by chemotherapy, in particular to a powder injection preparation of palonosetron for injection and its pharmaceutically acceptable salt and its preparation method. Background technique [0002] Palonosetron (palonosetron) is a new serotonin receptor antagonist, mainly used to prevent chemotherapy-induced nausea and vomiting symptoms. At present, there are water injection preparations on the market, which have a very good curative effect on the treatment of vomiting caused by chemotherapy in clinical practice, but the pH value and photostability of the water injection preparations are relatively poor, thus causing problems for the safety and effectiveness of clinical medication. certain influence. Contents of the invention [0003] The object of the present invention is to provide a powder injection preparation of pal...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/473A61P1/08
Inventor 周树忠王万青
Owner 杭州容立医药科技有限公司
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