Process for preparing alfuzosin hydrochloride

A technology for alfuzosin hydrochloride and an organic base, which is applied in the field of preparation of alfuzosin hydrochloride, can solve problems such as difficulty in realizing large-scale industrial production of alfuzosin hydrochloride, and achieves easy realization of reaction conditions, simplified operation, and reduced The effect of three waste pollution
CN1616438AActive Publication Date: 2005-05-18LUNAN PHARMA GROUP CORPORATION
1 Cites 4 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
LUNAN PHARMA GROUP CORPORATION
Publication Date
2005-05-18

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
Patent Text Reader

Abstract

The present invention discloses the preparation process of alfuzosin hydrochloride. N-methyl propylenediamine as material is condensed with 2-tetrahydrofuran formyl chloride or 2-tetrahydrofuran formic acid to obtain condensate; the condensate without being purified is then condensed with 2-chloro-4-amino-6, 7-dimethoxy quinazoline to obtain alfuzosin; and alfuzosin is finally reacted with hydrochloric acid to form alfuzosin hydrochloride. The said process has simple operation, low cost, high yield and easy-to-realize reaction conditions, and is suitable for industrial production.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to alfuzosin hydrochloride (N-[3-(4-amino-6,7-dimethoxy-2-quinazolinyl) methylamino] propyl) tetrahydro-2-furan carboxamide salt Salt) preparation method. Background technique

[0002] Alfuzosin hydrochloride (Alfuzosin hydrochloride) is N-[3-(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl)tetrahydro-2-furan carboxamide The common name for hydrochloride, its structural formula is:

[0003]

[0004] Alfuzosin hydrochloride is a quinazoline derivative that can selectively bind to the alpha of the prostate, prostatic capsule, proximal urethra and bladder fundus 1 -Receptor competitive binding, antagonizes α 1 - Receptor-mediated smooth muscle contraction. Alfuzosin hydrochloride can significantly reduce voiding disorder in clinical patients with benign prostatic hyperplasia, increase urine flow rate, and effectively improve the quality of life of patients. Alfuzosin hydrochloride was developed by the Beiezsdo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More