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Novel cyclopeptide anti-tumor, anti-virus antibiotic active compound

An antibacterial activity and compound technology, which is applied in the field of new cyclic peptide antitumor and antiviral antibacterial active compounds, can solve problems such as compounds that have not yet been reported, and achieve a good inhibitory effect.

Inactive Publication Date: 2005-05-18
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Such components have been isolated, but so far, there have been no reports of compounds with structures like Mixirin A

Method used

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  • Novel cyclopeptide anti-tumor, anti-virus antibiotic active compound
  • Novel cyclopeptide anti-tumor, anti-virus antibiotic active compound
  • Novel cyclopeptide anti-tumor, anti-virus antibiotic active compound

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Embodiment Construction

[0010] The raw material marine bacterium used in the present invention is collected from the sedimentary mud of the seabed near the North Pole, certainly raw material is not limited to above-mentioned area, is identified as Bacillus sp.

[0011] The marine bacterium Bacillus sp. is purified and cultured on peptone seawater medium (both solid medium and fermentation use this medium). The medium formula is: peptone 7g, yeast powder 2g, glucose 2g, seawater 1000ml.

[0012] The colony is opaque, wrinkled, jagged at the edge, rod-shaped, 0.6-2.7 μm×1.1-9.8 μm, positive for Gram staining, with spores around, and positive for contact enzymes. Based on this feature, it is identified as Bacillus sp.

[0013] A large number of fermented production bacteria MIX-62 Bacillus sp. strains were obtained to obtain 30L of fermented liquid. The bacterial liquid was slightly light yellow, clear, and had a slight odor. It was extracted with an equal amount of ethyl acetate, and then extracted with...

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Abstract

The present invention discloses a kind of antitumor, antiviral and antibacterial active cyclopeptide compound. The fermented liquid of Bacillus sp., which is marine bacteria collected from deposited marine mud, as the material is separated via solvent extraction and column chromatography to obtain one kind of new cyclic lipopeptide compound. The chemical structure of the compound is determined by means of high resolution mass spectral, nuclear magnetic resonance and other spectral technology. The compound is expected to become medicine for treating cancer, and Staphylococcus aureus and virus inflection.

Description

Technical field: [0001] The present invention relates to the extraction and isolation of biologically active compounds from the fermentation broth of marine bacteria, specifically a new cyclopeptide anti-tumor, anti-virus, and antibacterial active compound Mixirin A extracted and isolated from the fermentation broth of marine bacteria Bacillus sp. . Background technique: [0002] Marine microorganisms have proven to be a rich source of novel antibiotic, antineoplastic and antiinflammatory drugs (Fenical, W. Chem. Rev., 93, 1673-1683 (1993).). In recent years, a lot of active compounds with novel structures have been isolated from marine microbial metabolites. The research on marine microorganisms mainly includes marine bacteria, fungi, actinomycetes and marine cyanobacteria, among which the research on marine bacteria is the earliest. The most studied. Marine bacteria are divided into Gram-positive bacteria and Gram-negative bacteria, of which Gram-negative bacteria accoun...

Claims

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Application Information

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IPC IPC(8): A61K38/12A61P35/00C07K7/50C12P21/02
Inventor 裴月湖张海龙田黎
Owner SHENYANG PHARMA UNIVERSITY
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