Spironolactone dripping pills

A technology of spironolactone and dropping pills, which is applied in the fields of pill delivery, blood diseases, extracellular fluid diseases, etc. It can solve the problems of production workers' health impact, increase of patients' drug costs, and low bioavailability, so as to avoid the first-pass effect of liver and intestines, Enhanced bioavailability, accelerated dissolution and absorption effects

Inactive Publication Date: 2005-07-06
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of conventional tablets and capsules in preparation technology, selection of excipients and process, such oral preparations have long dissolution time, low dissolution rate, poor absorption, low bioavailability, and are prone to enterohepatic first-pass effect And other problems, thus affecting the full play of the drug effect, the same conclusion can be drawn from the manufacturer's instructions for spironolactone tablets
At the same time, conventional tablets and capsules have a large amount of auxiliary

Method used

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  • Spironolactone dripping pills

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Effect test

Embodiment Construction

[0045] Now with the test of several groups of concrete examples and the result thereof, with regard to the preparation method of spironolactone dripping pill of the present invention, be further explained, test is divided into two parts of single matrix and composite matrix.

[0046] Group 1: Tests with a single matrix

[0047] [formula]

[0048] 1 Drug active ingredient: spironolactone, English name Spironolactone; alias: spironolactone, spironolactone sterol, Antisterone, ALDACTONE;

[0049] 1.1 Chemical name: 17b-hydroxy-3-oxo-7a-(acetylthio)-17a-pregna-4-ene-21-carboxylic acid g-lactone;

[0050] 1.2 Molecular formula: C 24 h 32 o 4 S;

[0051] 2. Substrate: polyethylene glycol 2000、4000、6000、8000、10000、20000 , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc. pharmaceutical carrier;

[0052] 3. Proportion: take g or kg as the unit, by weight parts, ...

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Abstract

The invention discloses a pharmaceutical composition for treating edema diseases and cardiovascular and cerebrovascular diseases, in particular an oral drop pill preparation of the pharmaceutical composition with spironolactone as an active ingredient. The purpose of the present invention is to make up for the deficiencies of the prior art, to provide patients and medical workers with a medicine with large drug loading capacity, rapid drug release, rapid effect, high bioavailability, small toxic and side effects, low price and easy to take. Spironolactone drop pills. Take spironolactone as raw material, add surfactant polyethylene glycol and other substrates, heat until the pharmaceutical composition melt and/or emulsion and/or suspension containing spironolactone and substrate are obtained, put it into the dropping pill machine, drop into It is formed by shrinking in a condensing agent, taken out and wiped dry.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating congestive edema, liver cirrhosis ascites, nephrogenic edema, idiopathic edema and other edema diseases as well as cardiovascular and cerebrovascular diseases such as heart failure and high blood pressure, in particular a medicinal composition with spironolactone as the active agent. Oral preparations of pharmaceutical compositions prepared from ingredients. Background technique [0002] According to the P.1078 spironolactone item in the second part of the Pharmacopoeia of the People's Republic of China in 2000, the routine use of spironolactone is a diuretic, and the preparations for clinical use include spironolactone tablets and spironolactone capsules. [0003] The instruction manual of Jiangsu Huanghai Pharmaceutical Co., Ltd. [Spironolactone Tablets] explains the product as follows: [0004] Pharmacology and Toxicology The structure of this drug is similar to that of aldosterone,...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/58A61P7/10A61P9/04A61P9/12
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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