Spironolactone dripping pills

Abstract

The invention discloses a pharmaceutical composition for treating edema diseases and cardiovascular and cerebrovascular diseases, in particular an oral drop pill preparation of the pharmaceutical composition with spironolactone as an active ingredient. The purpose of the present invention is to make up for the deficiencies of the prior art, to provide patients and medical workers with a medicine with large drug loading capacity, rapid drug release, rapid effect, high bioavailability, small toxic and side effects, low price and easy to take. Spironolactone drop pills. Take spironolactone as raw material, add surfactant polyethylene glycol and other substrates, heat until the pharmaceutical composition melt and / or emulsion and / or suspension containing spironolactone and substrate are obtained, put it into the dropping pill machine, drop into It is formed by shrinking in a condensing agent, taken out and wiped dry.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating congestive edema, liver cirrhosis ascites, nephrogenic edema, idiopathic edema and other edema diseases as well as cardiovascular and cerebrovascular diseases such as heart failure and high blood pressure, in particular a medicinal composition with spironolactone as the active agent. Oral preparations of pharmaceutical compositions prepared from ingredients. Background technique [0002] According to the P.1078 spironolactone item in the second part of the Pharmacopoeia of the People's Republic of China in 2000, the routine use of spironolactone is a diuretic, and the preparations for clinical use include spironolactone tablets and spironolactone capsules. [0003] The instruction manual of Jiangsu Huanghai Pharmaceutical Co., Ltd. [Spironolactone Tablets] explains the product as follows: [0004] Pharmacology and Toxicology The structure of this drug is similar to that of aldosterone,...

AI Technical Summary

Problems solved by technology

Due to the characteristics of conventional tablets and capsules in preparation technology, selection of excipients and process, such oral preparations have long dissolution time, low dissolution rate, poor absorption, low bioavailability, and are prone to enterohepatic first-pass effect And other problems, thus affecting the full play of the drug effect, the same conclusion can be drawn from the manufacturer's instructions for spironolactone tablets

At the same time, conventional tablets and capsules have a large amount of auxiliary materials, and the volume of the tablets (or capsules) is relatively high, and the relative cost is also high, which not only increases the patient's medication cost, increases its economic burden, but also brings certain inconvenience to taking. , especially in patients with difficulty swallowing

In addition, conventional tablets, capsules, etc., due to the granulation process in production, are prone to produce dust, causing certain pollution to the environment, and will also have a certain impact on the health of production workers

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