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Nudiflower beautyberry leaf capsule or granule and preparation method thereof

A technology of naked flower purple beads and granules, which can be used in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as slow onset of action

Inactive Publication Date: 2005-07-06
HAINAN JIUZHITANG PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But Nude Flower Zizhu Tablets are pure extract tablets, which require a disintegration process in the body, and the onset of effect is relatively slow; in order to cover up the bitterness and odor of traditional Chinese medicine, a coating process is needed; The preference and acceptance of dosage forms are also different, and new dosage forms are urgently needed,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Take 1500g of Aurora nudiflora, add 8 times the amount of water, decoct twice at 95±5°C, the first time for 2 hours, and the second time for 1 hour, combine the decoctions, filter, and concentrate the filtrate until measured at 65°C After the specific gravity is 1.18±0.02, it is spray-dried to obtain dry extract powder. The dry extract powder is pulverized, passed through a 100-mesh sieve, added 100g of starch, granulated by a high-speed mixing granulator, dried by a boiling dryer, added with 3.5g of magnesium stearate, mixed evenly, and packed into 1000 hard capsules.

Embodiment 2

[0014] Take 1500g of Aurora nudiflora, add 8 times the amount of water, decoct twice at 95±5°C, the first time for 2 hours, and the second time for 1 hour, combine the decoctions, filter, and concentrate the filtrate until measured at 65°C After the specific gravity is 1.18±0.02, it is spray-dried to obtain dry extract powder. The dry extract powder is crushed and passed through a 100-mesh sieve, 494g of soluble starch and 6g of cyclamate are added, granulated by a high-speed mixing granulator, dried by a boiling dryer, mixed evenly and packed into granules of 3 grams per bag.

Embodiment 3

[0016] Take 1500g of Aurora nudiflora, add 8 times the amount of water, decoct twice at 95±5°C, the first time for 2 hours, and the second time for 1 hour, combine the decoctions, filter, and concentrate the filtrate until measured at 65°C After the specific gravity is 1.18±0.02, it is spray-dried to obtain dry extract powder. The dry extract powder is pulverized, passed through a 100-mesh sieve, added with 500g of sucrose powder and 250g of dextrin, granulated by a high-speed mixing granulator, dried by a boiling dryer, mixed evenly, and packed into granules of 4 g / bag.

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PUM

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Abstract

The invention relates to a nudiflower beautyberry leaf capsule or granule and preparation method thereof, which consists of boiling nudiflower beautyberry leaf with water, filtering boiled liquid, concentrating, spray drying, charging medically acceptable excipient, palletizing to obtain hard gelatin capsule or pelletized granule.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to a nudihuazizhu capsule or granule and a preparation method thereof. Background technique [0002] Nudiflora Hook.et Am., leaves ovate-lanceolate or short round, 10-22cm long, 3-7cm wide. There are irregular fine serrations on the edge, the leaf surface is dark green, and turns black after drying, and the back of the leaf has taupe hairs. The leaves of Nadihua Zizhu contain flavonoids, sugars, tannins, phenols, amino acids and organic acids. [0003] The naked flower purple pearl was first recorded in "Lingnan Herb Collection", and it has been recorded in the herbal and traditional Chinese medicine monographs of the past dynasties. Modern commercial production—Nude Flower Zizhu Tablets began in 1970. Nude Flower Zizhu Tablets is a Chinese patent medicine made from a single medicinal material, using the dried leaves of the Ve...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/48A61P7/04
Inventor 李伟李柏宋永强
Owner HAINAN JIUZHITANG PHARMACY
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