Preparation method of isoflurane

A technology of isoflurane and freon, applied in the field of preparation of 1-chloro-2, organic compounds, can solve the problems of high impurity content in final products, difficult to ensure the yield of isoflurane, difficult to achieve by repeated rectification, etc. The effect of easy control, improved yield and stable operation
CN1651377AActive Publication Date: 2005-08-10LUNAN PHARMA GROUP CORPORATION
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
LUNAN PHARMA GROUP CORPORATION
Publication Date
2005-08-10

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Abstract

A process for preparing isolfuothane from trifluoroethanol, N-methypyrrolidone and freon-22 includes such steps as etherifying and chloridizing.
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Description

technical field

[0001] The invention relates to a preparation method of an organic compound, in particular to a preparation method of 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether (ie isoflurane), and belongs to the field of medicine and chemical industry. Background technique

[0002] Isoflurane is a general inhalational anesthetic and is the isomer of enflurane. Animal experiments and clinical studies have shown that isoflurane has low biochemical transformation, low liver and kidney toxicity, small circulation inhibition, good muscle relaxation, rapid and stable induction and recovery, no spasmodic brain waves, good recovery and small side effects, etc. advantage.

[0003] There are many preparation methods of isoflurane reported in the literature, but the process conditions are relatively complicated, the synthesis route is long, and the cost is high. U.S. Patent US3535425 (1970) discloses a kind of preparation method of isoflurane, and its reaction route is: [...

Claims

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