Extraction method of ginkgolactone B and ginkgo lactone in ginkgo leaf

Abstract

A process for extracting ginkalide B and biobalide from gingko leaf includes such steps as baking gingko leaves, removing impurities, breaking, extracting in aqueous solution of alcohol, purifying by adsorptive column, extracting gingkalide purifying by alumina column, step crystallizing and recrystallizing.

Description

technical field

[0001] The invention belongs to a plant extract and relates to a method for separating and extracting ginkgolide B and bilobalide from ginkgo leaves. The ginkgolide B and bilobalide extracted by the invention are suitable for treating diseases caused by platelet activating factors and neurological diseases. Background technique

[0002] Ginkgolide and bilobalide are the only special substances found in Ginkgo biloba. Due to the complex spatial structure and variable chirality, the synthesis is very cumbersome. Currently, they can only be extracted from Ginkgo biloba leaves. Because of their specific effects in treating diseases, the research at home and abroad is relatively hot. There is no report on the simultaneous separation and extraction of ginkgolide B and bilobalide in foreign countries. There are reports on the extraction of ginkgolide, such as the Japanese Patent Publication Ping 3-24084 , Ginkgo biloba leaves are extract...