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Polymer composite with internally distributed deposition matter

A polymer and sediment technology, applied in the field of preparation of polymer composites, can solve problems such as difficult to control mixing, easy cracking of composites, insufficient mixing of materials, etc.

Inactive Publication Date: 2005-08-10
UNIVERSITY OF NOTTINGHAM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, these manufacturing methods result in inadequate and difficult-to-control mixing of the materials, resulting in the formation of large agglomerates, resulting in composites that are prone to fracture and are not suitable for commercial processing

Method used

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  • Polymer composite with internally distributed deposition matter
  • Polymer composite with internally distributed deposition matter
  • Polymer composite with internally distributed deposition matter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0129] Example 1 - Preparation of polymeric material

[0130] Poly(DL-lactic acid) (Alkermes Medisorb, low I.V. molecular weight = 85 kD, polydispersity = 1.4) was ground to a fine size powder with a pestle and mortar. Alternatively, the poly(DL-lactic acid) is forced out of a carbon dioxide pressurized vessel and through an orifice to form particles. Particulates are recovered from the centrifugal collector, while the carbon dioxide can be recompressed and recycled. The morphology of the particles depends on the antisolvent technique of particle generation from supercritical suspension (PGSS).

[0131] Polymers can also be produced as highly porous monoliths using supercritical fluid processing. In this case, porous scaffolds were prepared in molds prepared with 48-well tissue culture plates (Costar, USA). Weigh 12×100 mg (±1 mg) PLA, add to each well, and seal the mold in an autoclave. The autoclave was heated to 35°C and carbon dioxide was injected for 30 minutes to b...

Embodiment 2

[0132] Example 2 - Addition of biological material - protein

[0133] The protein, in this example avidin (Sigma) labeled with the fluorescent molecule rhodamine, was dissolved in distilled water to form aqueous solutions at concentrations of 1 μg / ml and 10 μg / ml. The liquid can also be selected from those liquids which dissolve biological material but not polymers. 0.5cm 3 Each portion of the protein solution was pipetted onto approximately 250 mg of the polymer sample and then kept in contact with the sample for a period of time (1 second to 48 hours). During this exposure, the liquid was removed by a lyophilization process. We have lyophilized various avidin-rhodamine and ribonuclease solutions (1-μg-250 mg / ml) added to both porous scaffolds and polymer powders within 48 hours. A control scaffold was prepared without protein addition.

[0134] Confocal fluorescence microscopy observations of the material confirmed that the avidin rhodamine was confined to the surface ...

Embodiment 3

[0135] Example 3 - Redistribution of biological material (protein)

[0136] One scaffold from each protein concentration sample in Example 2 was removed from the well as a control. The remaining stent samples were placed in a high-pressure autoclave, heated to 35 ° C, and the same procedure in Example 2 was used in CO 2 Replasticize in. Figure 4 A schematic of plasticization is shown. Confocal fluorescence microscopy of this reprocessed material revealed that the avidin rhodamine was redistributed within the polymer body ( Figure 4 ). Confocal microscopy observations were performed with a Leica TCS4D system (with Leica DMRBE upright fluorescence microscope and Argon-Krypton laser). The red fluorescence of TRITC avidin-rhodamine is excited with a 568nm laser.

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Abstract

A process for the preparation of a polymer composite comprising internally distributed deposition matter wherein the process comprises providing a deposit of deposition matter at the surface of a solid state polymer substrate, contacting the surface deposited polymer with a plasticising fluid or a mixture of plasticising fluids under plasticising conditions to plasticise and / or swell the polymer and internally distribute deposition matter, and releasing the plasticising fluid or fluids to obtain polymer composite.; A polymer composite comprising a porous or non porous polymer throughout which particulate deposition matter as hereinbefore defined is distributed with desired uniformity, preferably with high uniformity in excess of 80% for example in excess of 98%.; A scaffold comprising a polymer composite having internally distributed deposition matter; and use of the composite as a support or scaffold for drug delivery, for use in bioremediation, as a biocatalyst or biobarrier for human or animal or plant matter, for use as a structural component, for example comprising the polymer and optional additional synthetic or natural metal, plastic, carbon or glass fibre mesh, scrim, rod or like reinforcing for medical or surgical insertion, for insertion as a solid monolith into bone or tissue, as fillers or cements for wet insertion into bone or teeth or as solid aggregates or monoliths for orthopaedic implants such as pins, or dental implants such as crowns etc.

Description

field of invention [0001] The present invention relates to a process for the preparation of polymer composites which comprises contacting the polymer with a plasticizing fluid and deposits and isolating the polymer with internally distributed deposits. Also relates to polymer composites thus produced; devices for the manufacture of the polymer composites; polymer scaffolds; drug delivery devices and similar devices containing said composites of appropriate size and shape; to the polymer composites Use in the following fields of application: in the fields of biomedicine, catalysts, etc., as pharmaceutical or veterinary products; as products for the promotion of human or animal health or growth, structure, fragrance or cosmetics; as products for organic agriculture or crop protection Uses; more specifically, as biodegradable sustained-release products, or as biodegradable surgical implants, synthetic bone composites, tissue modules (module), etc., or as biocatalysts or biologica...

Claims

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Application Information

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IPC IPC(8): A61K47/30A61K9/00A61K9/16A61L27/00C08J3/20D06M23/00
CPCC08J3/203A61K9/1647A61K9/0024
Inventor S·M·豪德尔K·M·莎克谢夫M·J·惠塔克M·S·沃森
Owner UNIVERSITY OF NOTTINGHAM