Solid preparation taken through oral cavity of compound MEthoxyphEnaminE and preparation method

A technology of solid preparations and compound methoxyl, which is applied to respiratory diseases, active ingredients of heterocyclic compounds, drug combinations, etc., can solve the problems of discoloration of contents, poor fluidity of capsule contents, deformation and discoloration of inner capsule shell, etc.

Active Publication Date: 2005-08-31
ADVENCHEN LAB NANJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the compound methoxyphenamine capsules sold in the market are often unstable because one of the components, methoxyphenamine, is easy to cause moisture and the other component, aminophylline, will escape diethylamine when the moisture, temperature and other conditions change. Thereby affecting the stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Preparation of compound methoxyphenamine capsules

[0018] All the raw materials including methoxamine hydrochloride, narcotine, aminophylline, and chlorpheniramine maleate are crushed, and the main compound methoxamine is taken in the regular prescription amount, namely 25mg aminophylline, 12.5mg methyl hydrochloride Oxanamin, 7mg narcotine and 2mg chlorpheniramine maleate were added to 3.25mg glyceryl behenate, stirred and mixed for 50 minutes, and then 50mg calcium hydrogen phosphate and 2mg micronized silica gel were added and mixed well. Fill the above mixture in No. 4 capsules to obtain compound methoxyphenamine capsules.

Embodiment 2

[0019] Example 2: Preparation of compound methoxyphenamine capsules

[0020] All the raw materials including methoxamine hydrochloride, narcotine, aminophylline, and chlorpheniramine maleate are crushed, and the main compound methoxamine is taken in the regular prescription amount, namely 25mg aminophylline, 12.5mg methyl hydrochloride Oxyphenamine, 7 mg narcotine and 2 mg chlorpheniramine maleate were added to 2.56 mg of glyceryl behenate, stirred and mixed for 30 minutes, then 40 mg of calcium hydrogen phosphate and 1.5 mg of micronized silica gel were added and mixed well. Fill the above mixture in No. 4 capsules to obtain compound methoxyphenamine capsules.

Embodiment 3

[0021] Example 3: Preparation of compound methoxyphenamine capsules

[0022] Crush all the raw materials including methoxamine hydrochloride, narcotin, aminophylline, and chlorpheniramine maleate, and take the conventional prescription amount of compound methoxamine main drug, stir and mix for 55 minutes, and then add 50mg hydrogen phosphate Calcium and 1mg micronized silica gel are mixed evenly. Fill the above mixture in No. 4 capsules to obtain compound methoxyphenamine capsules.

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PUM

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Abstract

An orally-taken composite solide medicine containing methoxyphenamine is prepared from the methoxyphenamine hydrochloride, noscapine, euphyllin, chlorphenamine maleate and diluent chosen from 13 compounds including stearic acid, calcium hydrogen phosphate, microcrystalline cellulose, etc.

Description

Technical field [0001] The invention relates to a compound oral solid preparation of methoxyphenamine and a preparation method thereof. Background technique [0002] Asthma is the most common respiratory disease. It is caused by allergies, circulatory system or lung congestion, bronchial edema, kidney or heart disease, and central nervous system agitation. Compound methoxamine is based on the above-mentioned various causes and is based on the more effective drug ingredients methoxamine hydrochloride (a therapeutic agent for bronchial asthma), narcotine (antitussive), aminophylline (cardiotonic diuretic) and horse Chlorpheniramine (an antihistamine) and other asthma treatment agents formulated to effectively relieve the onset of cardiac asthma or bronchial asthma, inhibit coughing and various related symptoms. [0003] At present, the compound methoxenamin capsules sold on the market are often unstable because one of the ingredients, methoxenamin, is easy to attract moisture and t...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61P11/06A61P37/08
Inventor 周树忠胡雅芳
Owner ADVENCHEN LAB NANJING
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