Supercritical fluid analog moving bed chromatograph of ternary area

Abstract

The three-zone supercritical fluid analog movable bed chromatographic equipment includes 3-36 stuffing columns connected successively with back pressure regulator, with the output of the last stuffing column being connected to the input of the first one with back pressure regulator. All the inlets of the stuffing columns are connected with the flow phase inlet pipeline and sample feeding port pipeline, all the outlets of the stuffing columns are connected with extracting port pipeline and residue port pipeline, and the outlets of the extracting port pipeline and the residue port pipeline have cyclonic separators connected separately. The flow phase is supercritical fluid, and the present invention may operate in either pressure gradient operation mode or modifier gradient operation mode. The present invention has supercritical CO2 fluid as the flow phase and chiral fixed phase as stuffing, and may be used in splitting chiral medicine raceme in large scale.

Description

technical field [0001] The invention relates to an industrial preparation chromatographic separation device which contains an adsorbent for treating supercritical fluid, in particular to a three-part supercritical fluid simulated moving bed chromatographic device for splitting chiral drug racemate. Background technique [0002] The US Food and Drug Administration (FDA) issued guidelines for chiral drugs in March 1992, proposing a strategy for developing single-enantiomer drugs with less toxic side effects. Therefore, the development of racemic chiral drugs into high value-added single enantiomer drugs has become an unavoidable and urgently resolved major issue in the global pharmaceutical industry. [0003] In recent years, with the development of preparative chromatography technology and the commercialization of chiral stationary phases suitable for preparative use, preparative liquid chromatography has opened up a new way for the acquisition of single enantiomer drugs. Ph...

AI Technical Summary

Problems solved by technology

Although liquid phase simulated moving bed chromatography has shown such excellent performance, it still needs to consume 439 liters of organic solvent mobile phase to produce per kilogram of product, which means that the cost of solvent consumed to produce one ton of single enantiomer drug will be as high as nearly one hundred Ten thousand yuan, and at the same time, it will bring environmental problems that cannot be ignored

[0006] In addition, when the existing liquid-phase simulated moving bed chromatography is scaled up on an industrial scale, it involves the transportation of a large amount of organic solvents and high-pressure fluids, and these organic solvents are often flammable and explosive. Therefore, pumps, valves, instruments, The selection of key equipment such as electrical equipment and the overall design of the process workshop will put forward very strict safety requirements, which will increase equipment investment and operating costs

Images