Preparation method of chitin/zinc compound bactericide

A compound antibacterial agent, chitosan zinc technology, applied in the field of chemical biology of renewable resources, can solve the problems of harsh reaction conditions, ineffective effects, unfavorable large-scale production, etc., to achieve easy large-scale production, rich sources of raw materials, and preparation The effect of simple method

Inactive Publication Date: 2005-10-26
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the antibacterial activity of chitosan can be improved to a certain extent through the derivatization treatment of chitosan, the effect is not obvious, and it still cannot meet its application requirements, and the derivatization process of chitosan is complicated, and the reaction conditions are harsh Good for mass production
Metal ion is a traditional antibacterial agent with strong antibacterial activity, but its biological toxicity cannot meet the requirements of the current development of green non-toxic antibacterial agents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1: Weigh 1g of chitosan, add 100ml of 0.005g / ml dilute acetic acid solution, stir for 1-2h to dissolve, add 3.12g ZnSO under magnetic stirring 4 ·7H 2 For O powder, use a sodium hydroxide solution with a concentration of 0.05 mol / l with a pH value of 4.5, and continue to stir for 3-4 hours until the coordination equilibrium is reached. The stirring was stopped, and 200 ml of a 1:1 volume ratio of acetone:ethanol mixed solution was added to the solution to obtain a white mass precipitate. The precipitate was separated by suction filtration under reduced pressure, the precipitate was washed with 100 ml of absolute ethanol, and suction filtered under reduced pressure again to remove the detergent and the eluted unreacted ions. Repeatedly washing with 100 ml of deionized water twice, filtering the precipitate and vacuum drying to obtain a chitosan / zinc complex. Weigh 0.05g of chitosan / zinc complex and dissolve it in 10ml of 0.05mol / l dilute hydrochloric acid solution, a...

Embodiment 2

[0012] Example 2: Weigh 1g of chitosan sample, add 100ml of 0.01g / ml dilute acetic acid solution, stir for 1-2h to dissolve, add 1.56g ZnSO under magnetic stirring 4 ·7H 2 For O powder, use a sodium hydroxide solution with a concentration of 0.25 mol / l to have a pH value of 5.0, and continue to stir for 3-4 hours until the coordination equilibrium is reached. The stirring was stopped, and 200 ml of a 1:1 volume ratio of acetone:ethanol mixed solution was added to the solution to obtain a white mass precipitate. The precipitate was separated by suction filtration under reduced pressure, the precipitate was washed with 100 ml of absolute ethanol, and suction filtered under reduced pressure again to remove the detergent and the eluted unreacted ions. Repeatedly washing with 100 ml of deionized water twice, filtering the precipitate and vacuum drying to obtain a chitosan / zinc complex. Weigh 0.5g of chitosan / zinc complex and dissolve it in 10ml of 0.5mol / l dilute hydrochloric acid solu...

Embodiment 3

[0013] Example 3: Weigh 1g sample of chitosan, add it to a dilute acetic acid solution with a concentration of 0.015-g / ml, stir for 1-2h to dissolve, add 0.78g ZnSO under vigorous stirring 4 ·7H 2 For O powder, use a 0.5mol / l sodium hydroxide solution with a pH value of 5.5, and continue to stir for 3-4 hours until the coordination equilibrium is reached. The stirring was stopped, and 200 ml of a 1:1 volume ratio of acetone:ethanol mixed solution was added to the solution to obtain a white mass precipitate. The precipitate was separated by suction filtration under reduced pressure, the precipitate was washed with 100 ml of absolute ethanol, and suction filtered under reduced pressure again to remove the detergent and the eluted unreacted ions. Repeatedly washing with 100 ml of deionized water twice, filtering the precipitate and vacuum drying to obtain a chitosan / zinc complex. Weigh 1g of chitosan / zinc complex and dissolve it in 10ml of 1mol / l dilute hydrochloric acid solution, ad...

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PUM

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Abstract

A composite chitosan / Zn antibacterial agent with broad spectrum is prepared from chitosan and Zn ions through ionic coordination, depositing in the mixture of acetone and alcohol, washing and drying.

Description

Technical field [0001] The invention relates to a method for preparing a novel antibacterial agent by using a metal zinc complex of natural renewable resource chitosan, and belongs to the field of renewable resource chemical biology. Background technique [0002] Chitin is a natural polysaccharide extracted from the crustaceans of shrimps, crabs and other crustaceans and the cell walls of fungi. It is also the second largest biomass resource in nature after cellulose. Chitosan is a deacetylated derivative of chitin. It has good biocompatibility, biodegradability, natural non-toxicity and a variety of biological activities, especially spectral antibacterial properties, and because of its molecular chain has many amino groups Active groups such as, hydroxyl, etc. have high reactivity and are easily complexed with transition metal ions. In recent years, chitosan has received widespread attention as a natural antibacterial agent. However, compared with traditional antibacterial agent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/16
Inventor 杜予民王小慧
Owner WUHAN UNIV
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