Cepharanthine drip pill and its preparation method

A kind of Qianjintengsu and Qianjin's technology, which is applied in the field of Qianjintengsu dripping pills and its preparation, can solve the problems of the bioavailability of the first-pass effect of the liver and intestines, which is not conducive to improving the ability of patients to seek medical treatment, and is not conducive to the overall health level, so as to achieve the benefit of labor. Effects of protection and environmental protection, improvement of bioavailability, and drug safety

Inactive Publication Date: 2005-10-26
北京博智绿洲医药科技有限公司
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AI Technical Summary

Problems solved by technology

[0006] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicines, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic first-pass effect and low bioavailability after taking. Thus affecting the efficacy of the drug, and directly affecting the therapeutic effect
In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the human body. some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
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Embodiment Construction

[0025] Now with several groups of specific examples, the preparation method of the stephenicine dripping pills of the present invention will be further described.

[0026] Group 1: Tests with a single matrix

[0027] 1. Raw materials: Stephania;

[0028] 2. Substrate: polyethylene glycol (1000、2000、4000、6000、8000、10000、20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc.;

[0029] 3. Proportion: take g or kg as the unit, by weight parts, drug dry powder: matrix = 1:1~1:9;

[0030] 4. Prepare according to the process given in [Preparation Method] 4-7, and then you can get stephatrin dripping pills with different specifications.

[0031] [test results]

[0032] Test 1: In order to observe the difference in quality of the stephenol dripping pills prepared when the ratio of stephatrin and different substrates was 1:1, stepchceptin was mixed with polyethyle...

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Abstract

A dripping pill of stephanine for treating the leukocytopenia caused by radiotherapy and chemicotherapy is prepared from stephanine and medical carrier.

Description

technical field [0001] The present invention relates to a kind of medicine composition that has heat-clearing and blood-cooling effect, and is used for the treatment of leukopenia caused by radiotherapy and chemotherapy in tumor patients, and particularly relates to a Chinese medicinal material of stepchinenthin, which is prepared together with a pharmaceutically acceptable carrier as a matrix. A pharmaceutical composition orally prepared. Background technique [0002] According to the preparation method given in the ministerial drug standard WS-11166 (ZD-1166)-2002, the stephenin tablet is an oral preparation prepared from stephine as a raw material of traditional Chinese medicine. It has the function of clearing heat and cooling Blood effect, an oral tablet for treating tumor patients with leukopenia caused by radiotherapy and chemotherapy, has been clinically verified and has definite curative effect. It is a commonly used drug for clinical and family use to treat such di...

Claims

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Application Information

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IPC IPC(8): A61K31/4741
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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