Unlock instant, AI-driven research and patent intelligence for your innovation.

Non-injection preparation of growth hormone and purpose thereof

A technology for growth hormone and injection preparation, applied in the preparation of growth hormone and its application, protein preparation and its application field, can solve the problems of unacceptable, affecting biological activity, fragmentation of growth hormone peptide chain, etc., to achieve good chemical Effects on stability and biological activity

Inactive Publication Date: 2005-11-02
天津国韵生物科技有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) Fracture of the peptide chain: especially when the solution is polluted by protease, the peptide chain of growth hormone is broken, thereby affecting the biological activity
It is inconvenient and unacceptable for the additional supplementation of growth hormone secretion to decrease with the increase of age, if it is also achieved by injection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0032] Examples: The following examples are only used to illustrate the present invention, and should not be construed as any limitation to the present invention.

[0033] Raw materials: The reagents used in the present invention are all from SIGMA Company of the United States.

example 1

[0034] Example 1: Screening of Growth Hormone Stable Solutions

[0035] In the research design of the present invention, the basic buffer plus different combined formula solutions were used for research and screening, and finally eight groups of basic formulas were selected for the stability experiment of growth hormone in vitro. After each group of experiments is equipped, it is stored at room temperature (22-25°C) and protected from light. The chemical structure analysis and biological activity of growth hormone are carried out at one month, two months, three months and six months after storage. Determination. The experimental groups and formulation components are listed in the table below.

[0036] basic ingredients

STB-1

STB-2

STB-3

STB-4

STB-5

STB-6

STB-7

STB-8

rhGH

1mg / ml

1mg / ml

1mg / ml

1mg / ml

1mg / ml

1mg / ml

1mg / ml

1mg / ml

2mM chloride

calcium

+

0.4mM ...

example 2

[0056] Example 2: Human Trial-1

[0057] The present invention adopts STB-8, each milliliter contains 12 micrograms of growth hormone, and every 60 milliliters is filled into a spray bottle for volunteers to try out.

[0058] The choice of volunteers is mainly based on age and some age-related symptoms. These symptoms and manifestations are: (1) The trial participants seem to be easily and physically and mentally exhausted in the past one or two years, and their spirits are relatively tense, their attention is not concentrated, and their work efficiency is low. , which has not been the case in the past. (2) The trial subjects have poor sleep quality, or have insomnia, without past history. (3) After eating in the evening, I feel that my digestion is not good, and I feel bloated at night. (4) Feeling of discomfort in multiple joints or back, that is, the phenomenon of "lumbar and leg inflexibility". (5) The heartbeat is fast, generally 80 beats per minute. (6) Loss of libid...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The non-injection growth hormone preparation consists of growth hormone and growth hormone stabilizer. The growth hormone stabilizer is matter with chemical structure and bioactivity of stabilizing growth hormone and capacity of strengthening the penetration of growth hormone, and includes zinc, alcohol, polyalcohol, vitamin C, sodium citrate and amino acids. The non-injection growth hormone preparation is used to provide human body with foreign growth hormone to produce health care, beautifying and treatment effects.

Description

Technical field: [0001] The invention belongs to the field of protein preparation and its application, more precisely, it belongs to the field of preparation of growth hormone and its application. Background technique: [0002] Human growth hormone is an endocrine hormone produced and secreted by the eosinophilic granule cells of the anterior pituitary gland. This hormone is directly related to the growth and development of the human body and the maintenance of normal physiological functions. Growth hormone can also be expressed in vitro by recombinant DNA technology. There is only one amino acid difference between the growth hormone produced in vitro and the growth hormone synthesized in the human body. There is an extra methionine at the amino acid end of the natural hormone, but the biological effects of the two are the same. Therefore, the present invention utilizes growth hormone synthesized in vitro as a sample for in vitro and in vivo experiments. [0003] The secr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/27
Inventor 王正品吕渭川
Owner 天津国韵生物科技有限公司