Filtering-degerming Chinese medicine or animal-plant volatile oil or fat emulsion and preparing method

A technology for filtering bacteria, animals and plants, applied in the field of medicine, can solve the problems of reducing curative effect, easy decomposition of volatile oil, and increasing cost.

Inactive Publication Date: 2005-12-21
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The former has problems such as hemolysis and allergies, and there is a possibility of mutagenicity in long-term use
Extensive use of surfactants will not only increase the cost, but it is even more undesirable to reduce the curative effect, increase toxic and side effects, and even reduce the storage period of the drug.
The latter has many problems caused by high temperature sterilization, such as the physical stability of the preparation (stratification, aggregation, etc.), the chemical stability of raw and auxiliary materials, and many volatile oils are easy to decompose under high temperature and high pressure.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: Ligusticum chuanxiong oil emulsion

[0045] Prescription composition: Chuanxiong oil 0.1g, egg yolk phospholipid 0.5g, lipoic acid 0.05g, glucose 5g, appropriate amount of hydrochloric acid, the rest is water for injection, a total of 100ml.

[0046] Production method:

[0047] 1) Preparation of the oil phase: under the protection of nitrogen, add Ligusticum chuanxiong oil and egg yolk phospholipids into a beaker, stir vigorously until uniformly dispersed, cool down to 30°C, add lipoic acid, and stir vigorously for 5 minutes;

[0048] 2) Preparation of water phase: add glucose to water for injection, stir at 50°C for 5 minutes to dissolve completely (use activated carbon to depyrogenate if necessary);

[0049] 3) At 30°C, add the water phase to the oil phase and stir vigorously for 10 minutes to form colostrum;

[0050] 4) Adjust the pH value to 3 with an appropriate amount of hydrochloric acid solution;

[0051] 5) Through the homogenizer, the first step...

Embodiment 2

[0054] Prescription composition: Chuanxiong oil 1g, glyceryl caprylate 1g, soybean lecithin 0.5g, TPGS 0.5g, vitamin E for injection 0.1g, glucose 5g, appropriate amount of hydrochloric acid, the rest is water for injection, a total of 100ml.

[0055] Production method:

[0056] 1) Prepare the oil phase: under the protection of nitrogen, heat caprylic acid glycerin and vitamin E to 60°C, add soybean lecithin and TPGS, stir vigorously until dissolved, cool down to 20°C, add Ligusticum chuanxiong oil, and stir vigorously for 1 min;

[0057] 2) Preparation of water phase: add poloxamer and glucose into water for injection, stir and dissolve at 40°C (use activated carbon to depyrogenate if necessary);

[0058] 3) At 20°C, add the water phase to the oil phase and stir vigorously for 7 minutes to form colostrum;

[0059] 4) Use an appropriate amount of hydrochloric acid solution to adjust the pH value to 4;

[0060] 5) Through the homogenizer, the first step is to adjust the homog...

Embodiment 3

[0064] Prescription composition: 1g of angelica oil, 0.5g of caprylic acid glyceride, 0.5g of soybean oil, 2.5g of soybean lecithin, 0.5g of TPGS, 2.2g of glycerin, appropriate amount of hydrochloric acid (sodium hydroxide), and the rest is water for injection, a total of 100ml.

[0065] Production method:

[0066] 1) Prepare the oil phase: under the protection of nitrogen, heat caprylic acid glycerin and soybean oil to 60°C, add soybean lecithin and TPGS, stir vigorously until dissolved, cool down to 40°C, add the drug, and stir vigorously for 2 minutes;

[0067] 2) Preparation of water phase: add glycerin to water for injection, stir and dissolve at 40°C (use activated carbon to depyrogenate if necessary);

[0068] 3) At 40°C, add the water phase to the oil phase and stir vigorously for 5 minutes to form colostrum;

[0069] 4) Use an appropriate amount of hydrochloric acid (sodium hydroxide) solution to adjust the pH value to 7;

[0070] 5) Pass through the microfluidizer,...

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PUM

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Abstract

The present invention relates to a Chinese medicine or animal plant volatile oil (fat) emulsion and its preparation method. Said injection composition includes (by wt%) 0.1-10% of Chinese medicine or animal plant volatile oil (fat), 0%-10% of injection oil (including medium and long chain oil), 0.5%-15% of emulsifier, 0%-3% of emulsification adjuvant and 1%-10% of isoosmotic regulating agent. Besides, it also contains pH regulating agent, antioxidant and preservative (bacteria inhibitor). Said emulsion can be filtered and sterilized by adopting micropore filtering membrane with 0.3 micron or less than 0.3 micron or G6 incipient fusion glass funnel.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to a filter-sterilizable traditional Chinese medicine or animal and plant volatile oil or grease emulsion and a preparation method. Background technique: [0002]Chinese medicine or animal and plant volatile oil (grease) exists in almost all animals and plants (reference 1, research on the chemical composition of tea tree volatile oil "Chinese Tea" 2004; 2, research on analgesic and anti-inflammatory effects of bornyl acetate in Amomum volatile oil "Chinese Medicinal Materials" 2004; 3. Analysis of the chemical components of the volatile oil in ephedra "Journal of Xinjiang University" Natural Science Edition 2004; 4. The chemical components of the volatile oil of Guangxi Ling vanilla "Journal of Plant Resources and Environment" 2004; 5. The volatile oil of St. John's wort Chemical composition "Xinjiang Traditional Chinese Medicine" 2004; 6. GC-MS analysis of the chemical component...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 邓意辉吴琼徐速王绍宁张玲玲
Owner SHENYANG PHARMA UNIVERSITY
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