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Cucurbitacine liposome and its prepn. method

A technology of liposome and cucurbitacin, which is applied in the field of medicine, can solve the problems of low bioavailability, achieve the effect of improving curative effect and poor oral absorption

Inactive Publication Date: 2006-01-25
胡才忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Researchers from West China Medical College of Sichuan University studied cucurbitacin polylactic acid nanoparticle freeze-dried injection; the bioavailability is low, and there is no recommendation for making cucurbitacin into liposomes and proliposomes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Preparation of cucurbitacin liposomes by ethanol injection method: take soybean lecithin, cholesterol, VE and add absolute ethanol to dissolve, inject into cucurbitacin aqueous solution, stir at constant temperature and high speed, evaporate under reduced pressure to remove ethanol, pass through a microporous membrane to granulate, and obtain cucurbitacin The encapsulation efficiency of liposomes can reach 62.8%.

Embodiment 2

[0012] Prepare cucurbitacin liposomes by film dispersion method: get soybean phospholipids, cholesterol, VE and dissolve them in 150ml eggplant-shaped bottle with 15ml chloroform, form a film under reduced pressure on a rotary thin film evaporator and remove all organic solvents, add 10ml cucurbitacin aqueous solution water The cucurbitacin liposomes are obtained by passing through a microporous membrane to obtain cucurbitacin liposomes, and the encapsulation efficiency can reach 60.1%.

Embodiment 3

[0014] Prepare cucurbitacin liposomes by reverse-phase evaporation: Weigh soybean lecithin, cholesterol, VE and add 5ml chloroform to dissolve, then add 10ml ether, then add 15ml cucurbitacin in phosphate buffer, bath ultrasonic to form a homogeneous single phase system, evaporated under reduced pressure to remove chloroform ether until the gel was formed, continued to evaporate under reduced pressure for 5 to 10 minutes, and vortexed until the aqueous suspension, that is, liposomes, formed. The encapsulation efficiency can reach 27.5%.

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Abstract

A cucurbitacin lipid with high absorptivity, biologic utilization rate and stability for treating tumor and hepatitis and improving immunity is prepared proportionally from vinpocetin, phosphatide, cholesterol and the supporting agent chosen from sorbitol, mannitol, cane sugar, sodium chloride, water-soluble starch, etc.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a cucurbitacin liposome (including proliposome) and a preparation method thereof. Background technique [0002] Cucurbitacin is a component extracted from the stalk of melon, a traditional Chinese medicine. It has a variety of biological activities, such as cytotoxicity, anti-tumor, liver protection, anti-hepatitis, and immune function improvement. It mainly contains cucurbitacin B, E, etc., which contains more than 80% cucurbitacin B, which is an effective ingredient for treating hepatitis and liver cancer. Cucurbitacin Tablets are used to treat chronic hepatitis --- Cucurbitacin Tablets Pharmacy Bulletin 1986, 21 (6): 357), through clinical trials in 13 hospitals in Shanghai, Beijing, Chongqing and other places, the effective rate is 75.2%, and the marked rate is 44.6% Chinese Herbal Medicine 1987, 18(10): 1984, 3(2): 21-22, Pharmacology and Clinical Application of Cucurbitac...

Claims

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Application Information

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IPC IPC(8): A61K31/57A61K9/127A61K9/20A61K9/16A61K9/48A61P1/16A61P35/00A61P31/12
Inventor 胡才忠
Owner 胡才忠
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