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Acoustical contrast medium of polymer material and its prepn

A technology of polymer polymerization and acoustic contrast agent, which can be applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agent, etc., can solve the problems of wide particle size distribution, unstable properties, application limitations, etc., and achieve wide application prospects and promotion and application value. Effect

Active Publication Date: 2006-03-01
冉海涛 +2
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitations of preparation methods and shell materials, this type of acoustic contrast agent has disadvantages such as wide particle size distribution, unstable properties, short duration in the body, and obvious rear sound attenuation, and the price of biological products is expensive. Applications are very limited

Method used

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  • Acoustical contrast medium of polymer material and its prepn
  • Acoustical contrast medium of polymer material and its prepn
  • Acoustical contrast medium of polymer material and its prepn

Examples

Experimental program
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Effect test

Embodiment 1

[0050] 1. Synthesis of Acoustic Contrast Agents from Polymer Materials

[0051] Reagents: polylactic / glycolic acid (PLGA): polyvinyl alcohol (PVA), dichloromethane, isopropanol, camphor, ammonium chloride. purchased from Chongqing Pharmaceutical Company.

[0052] Equipment: electronic balance, acoustic vibration instrument (XL2020), high-speed dispersion homogenizer, magnetic stirrer, high-speed centrifuge, -45°C refrigerator, freeze dryer, blood cell counter, etc.

[0053] Method steps:

[0054] (1) Add 0.1 g of camphor into 20 ml of dichloromethane, stir well to dissolve it completely (Solution-A).

[0055] (2) Add 1.0 g of high molecular polymer material PLGA into solution-A, and stir until it is completely dissolved (solution-B).

[0056] (3) Add 3ml of 5% ammonium chloride into solution-B, and immediately vibrate (XL2020 acoustic vibrator, 4-10 file) for 40s to form a milky white emulsion (W / O microspheres, the particle size is 0.4-5μm It can be controlled by changing...

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Abstract

The present invention relates to one kind of microbubble acoustic contrast medium of new type polymer material capable of being degraded naturally in body and the preparation process of the contrast medium with or without coated medicine or gene. The preparation process of the acoustic contrast medium with artificially synthesized biodegradable polymer material includes emulsification, preparing microballoon of polymer material shell and coated volatile organic solvent and water solvent, and spraying or freezing to dry and to volatize or sublime the solvent so as to obtain the microbubble acoustic contrast medium. The present invention has the advantages of natural degradation of the shell material, homogeneous and controllable grain size, good development effect, long lasting time, less back attenuation, capacity of coating medicine or gene, capacity of realizing located release of medicine and located transfection of gene, etc.

Description

technical field [0001] The invention relates to an acoustic contrast agent, specifically a novel macromolecule material microbubble acoustic contrast agent that can be naturally degraded in vivo. The invention also relates to the preparation method of the contrast agent and the encapsulated drug or gene contrast agent. Background technique [0002] Tissue acoustic contrast is a new technology that has been gradually developed in recent years with the continuous improvement of acoustic contrast agent preparation technology and image development technology. Acoustic contrast agents can enhance the gray-scale imaging of tissues, enhance color Doppler blood flow signals, and improve the detection rate of lesions and Doppler blood flow signals, and will play a huge role in the ultrasonic diagnosis and differential diagnosis of diseases. Broad application prospects are the focus and development direction of current medical ultrasound imaging research. [0003] The microbubble aco...

Claims

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Application Information

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IPC IPC(8): A61K49/06
Inventor 冉海涛王志刚任红郑元义张群霞凌智渝
Owner 冉海涛
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