Chinese medicine volatoile oil self-mciro emulsifying nano composition and preparing method

A nano-composition and self-microemulsification technology, which is applied in pharmaceutical formulations, emulsion delivery, plant raw materials, etc., can solve the problems of unacceptable by patients, poor affinity of volatile oil, and influence on curative effect, so as to avoid demulsification and increase dispersion , Improve the effect of bioavailability

Inactive Publication Date: 2006-03-22
SHANGHAI INST OF PHARMA IND CO LTD
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the affinity between volatile oil and biofilm is poor, which affects the curative effect, and its peculiar smell makes it difficult for patients to accept it.

Method used

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  • Chinese medicine volatoile oil self-mciro emulsifying nano composition and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 2g of mugwort leaf oil and 1g of asarum oil and mix them evenly for later use. Add 3g of polyoxyethylene hydrogenated castor oil and 1g of polysorbate. After mixing evenly, add 200g of water and stir while adding. The inhalation solution of the present invention.

[0026] figure 1 It is a three-phase diagram of oil phase, water phase and surfactant phase. 1 is the microemulsion area, and 2 is the gel area.

[0027] Depend on figure 1 It can be seen that in the gel zone 2, the three-phase mixture is an almost transparent semi-solid that cannot flow freely, and the semi-solid can be put into water and self-emulsify to a viscosity similar to that of water, free-flowing, with little or no Blue fluorescent liquid, in which volatile oil is dispersed in nanometer size (<200nm); in microemulsion zone 1, drug-containing droplets are in nanometer size (within 200nm, more preferably within 100nm), and the viscosity is similar to that of water free-flowing liquid with lit...

Embodiment 2

[0029] Take 2g of mugwort leaf oil and 10g of pepper eye oil, mix well and set aside. Add 15g of polyoxyethylene hydrogenated castor oil and 5g of polysorbate. After mixing evenly, add 200g of water and stir while adding. The inhalation solution of the invention has the effect of rapidly relieving asthma.

Embodiment 3

[0031] Take patchouli oil 5.4g, perilla leaf oil 2.6g, mix well. Add 4 g of polysorbate and 6 g of polyoxyethylene hydrogenated castor oil and homogenize for 10 minutes with a high-speed homogenizer. Add 300g of water, pour in the previously prepared volatile oil mixture, and continue homogenizing for 20 minutes. After being filtered with a 0.45um microporous membrane, it is filled into a brown glass bottle according to the required dose to obtain the oral liquid of the Chinese medicine volatile oil self-microemulsified nano composition of the present invention. The prescription avoids the use of organic solvents in the preparation process, thereby reducing environmental pollution and production costs.

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Abstract

The Chinese medicine volatile oil self micro emulsifying nanometer composition consists of Chinese medicine volatile oil 0.2-40 wt%, surfactant 0.4-80 wt%, co-surfactant 0-40 wt%, and water 0-99.40 wt%. The present invention applies self micro emulsifying technology in Chinese medicine volatile oil to make medicine, such as soft capsule and oral liquid, self micro emulsified in body to nanometer size, or make medicine, such as injection and inhalant, existing in bacteria-free solution. The prepared self micro emulsifying nanometer composition has reduced irritation and toxicity, raised absorption rate and mucous membrane penetrating capacity, raised bioavailability, raised curative effect and improved patientí»s compliance.

Description

technical field [0001] The invention relates to a self-microemulsified nanometer composition of volatile oil of traditional Chinese medicine and a preparation method thereof. Background technique [0002] The volatile oils in traditional Chinese medicine are a kind of biologically active components, also known as essential oils. Usually it is a general term for the water-immiscible volatile oily components obtained from steam distillation of traditional Chinese medicine. Volatile oil is usually an oily liquid with a special strong odor, which can be evaporated at room temperature, soluble in concentrated ethanol and most organic solvents, and almost insoluble in water; it is sensitive to the influence of air, sunlight and temperature, and is easy to decompose spoiled. And the affinity of volatile oil and biofilm is poor, thereby influences curative effect, and its peculiar smell causes patient to be unacceptable. Oral preparations are the most used in research and clinica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/107
Inventor 金方闻聪施丽西
Owner SHANGHAI INST OF PHARMA IND CO LTD
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