Medicinal composition for treating arthritis

A composition and arthritic technology, applied in the field of compositions containing human urinary trypsin inhibitor and hyaluronic acid, can solve the problems of slow degradation of hyaluronic acid, long action time and the like, achieve inhibition of development, safe use, reduced The effect of treatment differences

Active Publication Date: 2006-03-29
GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reason for this is that hyaluronic acid with a higher molecular weight degrades relatively slowly and acts longer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Preparation of Human Urine Trypsin Inhibitor (UTI) Solution

[0018] Take 25 million units of ulinastatin, add 5 grams of mannitol, and dissolve with an appropriate amount of water for injection, adjust the pH to neutral, add water for injection to 1000 ml, filter aseptically, and divide into 1000 ampoules to obtain the product.

Embodiment 2

[0019] Example 2 Preparation of Sodium Hyaluronate Solution

[0020] Dissolve 2 grams of sodium hyaluronate in an appropriate amount of normal saline for injection, adjust the pH to neutral, add normal saline for injection to 200ml, filter aseptically, and divide into 1000 prefilled syringes to obtain the product.

Embodiment 3

[0021] Example 3 Preparation of Human Urine Trypsin Inhibitor and Sodium Hyaluronate Composition Preparation

[0022] Add 2 grams of sodium hyaluronate to 5 million units of human urinary trypsin inhibitor, adjust the pH to neutral, add physiological saline for injection to 200ml, filter aseptically, and divide into 1000 prefilled syringes to obtain the product.

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PUM

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Abstract

A composite medicine in the form of freeze-dried powder injection or liquid injection for treating osteoarthritis and rheumatoid arthritis is prepared from ulinastatin (a human Urinary trypsin inhibitor), sodium hyaluronate and optional mannitol, glycine and dextran.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating arthritis, especially a composition containing human urinary trypsin inhibitor and hyaluronic acid. Background technique [0002] The present invention relates to two medicines-human urinary trypsin inhibitor and hyaluronic acid; and two diseases-osteoarthritis and rheumatoid arthritis. The state of the art in the corresponding field is respectively described as follows. [0003] Urinary Trypsin Inhibitor (UTI, ulinastatin, ulinastatin) is a protease inhibitor isolated and purified from human urine, a glycoprotein with a molecular weight of 67000D. The protein is a broad-spectrum hydrolase inhibitor, and has inhibitory effects on various hydrolase including trypsin, elastase, and hyaluronidase. Ulinastatin for injection, a pharmaceutical preparation containing this substance as an active ingredient, is mainly used for the treatment of acute pancreatitis, acute circulatory failure, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/57A61K31/728A61P19/02A61K31/28
Inventor 傅和亮刘展欣苗丕渠侯永敏
Owner GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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