Ursine fat injection emulsion, and its prepn. method

A seal oil and emulsion technology, which is applied in the fields of pharmaceutical formula, emulsion delivery, medical preparations of non-active ingredients, etc., can solve the problems of low unsaturated fatty acid content and unsatisfactory properties of raw material oil, etc.

Inactive Publication Date: 2006-04-12
中国生化制药工业协会
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0038] 3. Inadequacies of traditional fat emulsion injection
[0043] At present, many countries have successfully applied nutritional infusion fat emulsion to clinical practice, but these emulsions are not satisfactory in terms of raw material oil properties, and most of the unsaturated fatty acids are omega-6 type, while omega-3 polyunsaturated very low in fatty acids

Method used

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  • Ursine fat injection emulsion, and its prepn. method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0157] To prepare 1000 grams of seal oil injection emulsion, include the following steps:

[0158] 1. Take 100 grams of water for injection, heat it to 40°C, add 2 grams of F68 and 12 grams of egg yolk lecithin, and crush it with an ultrasonic crusher to a uniform phospholipid dispersion;

[0159] 2. Dissolve 10 grams of glycerol with 40 grams of water for injection, filter it with a 0.2 μm membrane, and add it to the phospholipid dispersion;

[0160] 3. Take 210 grams of purified fur seal oil. Dissolve 0.05 g of vitamin E in the oil, filter it through a 0.2 μm membrane, and heat it to 40°C, then slowly add it to the phospholipid dispersion, and add it while ultrasonic emulsification. After adding the oil, add water for injection to 1000 grams of emulsion, and then continue ultrasonic emulsification for 5 minutes to make a uniform primary emulsion;

[0161] 4. G for initial emulsion 1 Filter through a vertical melting glass filter with a pore size of 20 μm, and then use a hig...

Embodiment 2

[0166] To prepare 1000 grams of seal oil injection emulsion, include the following steps:

[0167] 1. Take 100 grams of water for injection, heat it to 55°C, add 1.2% egg yolk lecithin, and crush it with an ultrasonic crusher to a uniform phospholipid dispersion;

[0168] 2. Dissolve 25 grams of sorbitol and 3 grams of sodium oleate for injection with 200 grams of water for injection, filter them with a 0.2 μm membrane, and add them to the phospholipid dispersion;

[0169] 3. Take 300 grams of purified fur seal oil, dissolve 0.1 grams of di-tert-butyl-p-cresol in the oil, filter it through a 0.2 μm membrane, and heat it to 55°C, then slowly add it to the phospholipid dispersion, and add while ultrasonic emulsification. The speed of adding oil is limited to the appearance of no visible oil droplets on the water surface. After the oil is added, add water for injection to 1000 grams of emulsion, and then continue ultrasonic emulsification for about 10 minutes to make a uniform pr...

Embodiment 3

[0175] To prepare 1000 grams of seal oil injection emulsion, include the following steps:

[0176] 1. Take 60 grams of water for injection, heat it to 70°C, add 6 grams of egg yolk lecithin, and crush it with an ultrasonic crusher to a uniform phospholipid dispersion;

[0177] 2. Dissolve 50 grams of glucose and 0.1 grams of cholic acid with 100 grams of water for injection, filter them with a 0.2 μm membrane, and add them to the phospholipid dispersion;

[0178] 3. Take 500 grams of purified fur seal oil, dissolve 0.2 grams of p-hydroxytert-butyl anisole in the oil, filter it through a 0.2 μm membrane, and heat it to 70°C, then slowly add it to the phospholipid dispersion, and add it while ultrasonic emulsification, The speed of adding oil is limited to the appearance of no visible oil droplets on the water surface. After the oil is added, add water for injection to 1000 grams of emulsion, and then continue ultrasonic emulsification for about 30 minutes to make a uniform prim...

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Abstract

An emulsified injection of fur seal fat suitable for the patients of carbohydate metabolism dis-function and insulin tolerance is proportionally prepared from the purified fur seal fat, emulsifier, isotonic regulator, anti-oxidizing agent and the water for injection through ultrasonic emulsifying.

Description

technical field [0001] The invention relates to a seal oil injection emulsion and a preparation method thereof. Background technique [0002] Fur seals are deep-sea mammals. They live in the alpine waters of -50°C within the Arctic Circle. They feed on precious cod. They have a thick layer of fat under their skin and are rich in omega-3 polyene fatty acids. The fur seal oil extracted from the unpolluted sea dog fat in northern Canada contains not only three important omega-3 polyene fatty acids: EPA (Eic-osapen-taenoic Acid, eicosapentaenoic acid), DPA (Docosapentaenoic Acid) , Docosahexaenoic acid) and DHA (Docosahexaenoic Acid, docosahexaenoic acid), and the total content is more than 20%. After years of research in the medical community, it has been confirmed that these three fatty acids have a variety of unique biological activities on the human body: EPA can improve blood circulation, soften blood vessels, adjust blood lipids, lower blood pressure and blood sugar, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/12A61K9/107A61P3/02A61K35/35A61K47/22A61K47/24
Inventor 徐康森王召乐嘉静李湛君
Owner 中国生化制药工业协会
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