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Method for extracting efficient component from mulberry leaf

A technology for active ingredients and mulberry leaf extracts, which is applied in the field of extracting active ingredients from mulberry leaves of plants, can solve problems such as easy oxidation in the purification process, and achieve the effects of high selectivity and low oxidation resistance.

Inactive Publication Date: 2006-04-26
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is to provide a method for extracting active ingredients from mulberry leaves, so as to overcome the defect that the purification process in the prior art is easy to oxidize

Method used

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  • Method for extracting efficient component from mulberry leaf

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1 kg of mulberry leaf is extracted with 5 kg of water by a conventional method, and 200 g of D818 adsorption resin is added to the extract, stirred for 1 hour and then filtered. In the resin, the weight content of the mulberry leaf water-soluble extract is 1.5%, in the mulberry leaf water-soluble extract, the weight content of deoxynojirimycin alkaloids is 1.0%, and the weight content of mulberry leaf flavonoids is 3.0%;

[0022] Put the resin adsorbed with solute in the extraction kettle, and continuously feed CO 2 For elution, CO 2 The throughput is 5 kg / hour;

[0023] The extraction temperature is 35°C, the pressure is 10MPa, and the CO that flows out of the extraction tank after 1.5 hours of extraction is collected 2 , depressurized to atmospheric pressure, CO 2 Empty, obtain the residue after pressure relief, analyze by high performance liquid chromatography, deoxynojirimycin alkaloid content is 5.7%, mulberry leaf flavonoid is 47%. The liquid chromatogram is a...

Embodiment 2

[0025] After 1 kilogram of mulberry leaf was extracted with 5 kilograms of water, the extract flowed through the adsorption column (80 mm in diameter) filled with 200 grams of HZ802 adsorption resin respectively. In the resin, the weight content of mulberry leaf water-soluble extract was 0.2%. In the leaf water-soluble extract, the weight content of deoxynojirimycin alkaloids is 0.6%, and the weight content of mulberry leaf flavonoids is 2.2%;

[0026] Put the resin adsorbed with solute in the extraction kettle, and continuously feed CO 2 , calculated per kilogram of resin adsorbed with water-soluble extract of mulberry leaves, CO 2 The throughput is 10 kg / hour;

[0027] The extraction temperature is 60°C, the pressure is 15MPa, and the CO outflowing from the extraction tank after 6 hours of extraction is collected. 2 , depressurized to atmospheric pressure, CO 2 Empty to obtain the residue after pressure relief, and analyze by high performance liquid chromatography, the co...

Embodiment 3

[0029] 2 kg of traditional Chinese medicine mulberry leaves are extracted with 7 kg of water, 100 g of adsorption resin HZ818 and 100 g of ion exchange resin D315 are added to the extract for adsorption, stirred for 1 hour and then filtered. In the resin, the weight content of the mulberry leaf water-soluble extract is 1%, in the mulberry leaf water-soluble extract, the weight content of the deoxynojirimycin alkaloid is 1.1%, and the weight content of the mulberry leaf flavone is 3.0%;

[0030] Put the resin adsorbed with solute in the extraction kettle, and continuously feed CO 2 For elution, CO 2 The feed rate is 25 kg / h, the extraction temperature is 65°C, and the pressure is 10MPa. CO collected from the extraction tank after 4 hours of extraction 2 , depressurized to atmospheric pressure, CO 2 Empty to obtain the residue after depressurization, analyzed by high performance liquid chromatography, the content of deoxynojirimycin alkaloid is 7.2%, and the content of mulberr...

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Abstract

The invention discloses a method for extracting efficient component from mulberry leaf comprising the following steps, placing resin with adsorbed mulberry leaf extract into an abstraction still, letting in CO2 continuously for abstraction and elution, collecting CO2 from the abstraction still, dropping pressure to normal pressure, evacuating CO2 or compressing for reuse, thus obtaining pressure released active constituent of mulberry leaf.

Description

technical field [0001] The invention relates to a method for extracting effective components of mulberry leaves, in particular to a method for extracting deoxynojirimycin alkaloids and mulberry flavonoids from mulberry leaves. Background technique [0002] Mulberry is a plant of the Moraceae family. The alkaloids and mulberry leaf flavonoids in the dried mulberry leaves are one of the active ingredients of the mulberry leaves. Its active ingredients can be divided into two types: fat-soluble and water-soluble. For example, mulberry phenolic acid is a water-soluble ingredient, which can increase coronary artery flow, and is an effective ingredient for anti-myocardial ischemia and improving microcirculation. Among them, protocatechualdehyde is The active ingredient of anti-angina pectoris, mulberry leaf flavone is the main ingredient in the treatment of coronary heart disease. Because of its therapeutic effect on the cardiovascular system, it is widely used clinically. Alkalo...

Claims

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Application Information

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IPC IPC(8): A61K36/605A61P3/10
Inventor 侯惠民王浩
Owner SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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