Method of inhibiting neonate tumour blood vessel

A technology for tumor angiogenesis and regeneration, applied in the field of tumor prevention and treatment, can solve problems such as inhibiting endothelial cells, and achieve the effects of inhibiting angiogenesis, inhibiting growth and metastasis, and reducing the number of small blood vessels

Inactive Publication Date: 2006-06-14
NANJING UNIV
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AI Technical Summary

Problems solved by technology

[0005] At present, there are no research reports at home and abroad that inhibit the growth of endothelial cells to control tumors by blocking the water metabolism pathway of endothelial cells - aquaporin

Method used

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  • Method of inhibiting neonate tumour blood vessel
  • Method of inhibiting neonate tumour blood vessel
  • Method of inhibiting neonate tumour blood vessel

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Experimental program
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Embodiment Construction

[0015] 1. Experimental animals:

[0016] C57BL / 6 mice, female, weighing 18-20 g, were provided by the Experimental Animal Center of Peking University Health Science Center. Lewis lung cancer tumors were purchased from the Institute of Materia Medica, Chinese Academy of Medical Sciences.

[0017] 2. Drugs and reagents:

[0018] Acetazolamide, acrylamide (Acrylamide, Acry), methylene bisacrylamide (N, N-Methylene-bis-Acrylamide, Bis) were purchased from Sigma Company; Ammonium persulfate (Ammoniumpersulfate, AP), sodium dodecylsulfonate ( Sodium dodecyl sulfate, SDS), TEMED were purchased from Bio-RAD; alkaline phosphatase-labeled goat anti-rabbit IgG was purchased from Bio-RAD; rabbit anti-human AQP1 antiserum was donated by Professor Verkman, University of California, San Francisco; Chromogenic reagents BCIP and NBT are products of Clontech; immunohistochemistry kits are products of Zymed Company of the United States; other reagents are of domestic analytical grade.

[0019...

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Abstract

A method for suppressing the neogenesis of tumorí»s blood vessel features that the newly disclosed water channel or aquaporin (AQP), which is a specific pore channel for transferring water on cell membrane and has rich expression on the endothelial cell of blood vessel, has the direct control action to the generation of blood vessel, and if the intermembrane water transfer of AQP is blocked, the generation of blood vessel can be suppressed.

Description

1. Technical field [0001] The invention belongs to the technical field of tumor prevention and treatment. 2. Background technology [0002] Angiogenesis is the basis of tumor malignant growth and metastasis. The continuous growth, invasion and metastasis of tumors depend on sufficient microangiogenesis and blood supply. When the tumor body diameter exceeds 1-2mm, the absorption of nutrients and the discharge of metabolic wastes will be limited, which will affect the further growth of tumors. Solid tumors only have Angiogenic phenotype is required for malignant growth and successful metastasis. [0003] Water channel (water channel), also known as aquaporin (Aquaporin, AQP), is a family of homologous inner membrane proteins discovered in recent years. It is a specific channel for transporting water on mammalian and plant cell membranes. Ten water channels identified from mammalian tissues. The expression of AQP1 protein is abundant on vascular endothelial cells. Existing ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61K49/00A61P35/00
Inventor 项阳李学军李涛
Owner NANJING UNIV
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