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Microporous bone cement and bone paste

A technology of bone cement and microporous bone, used in bone implants, medical science, prostheses, etc., can solve the problems of loose prosthesis, inability to repair bone defects, normal bone necrosis, etc., to reduce the normal bone body. Necrosis, reducing loosening and rework, ensuring a strong bond

Inactive Publication Date: 2006-08-02
北京茵普兰科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The replaced prosthesis works well at first, but long-term clinical follow-up shows that the prosthesis will loosen over time, which is due to the detachment of the interface between the bone cement and the bone body. Within 10-20 years after the operation, a considerable number of patients need to perform revision surgery, that is, to re-implant the prosthesis
In addition, the curing temperature of the bone cement during the operation is as high as 90°C, which can easily lead to the necrosis of the normal bone body connected with the prosthesis
[0003] In addition, the bone plaster currently popular on the market has low mechanical strength and cannot be used for repairing bone defects in the weight-bearing parts of the human body.

Method used

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  • Microporous bone cement and bone paste
  • Microporous bone cement and bone paste
  • Microporous bone cement and bone paste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] [Example 1] Preparation of Microporous Bone Cement

[0044] After mixing 88g of polymethylmethacrylate, 2g of benzoyl peroxide and 10g of barium sulfate, sterilize to make 100g of ordinary bone cement powder; take 49ml of methylmethacrylate, N, N-dimethylterephthalene After mixing amine 1ml, add 5×10 -4 g Hydroquinone is made into common bone cement liquid, wherein the concentration of hydroquinone in the bone cement solution is one hundred thousandth of a gram per liter. Take 40 g of ordinary bone cement powder and 20 ml of ordinary bone cement liquid, and pack them separately after sterilization to obtain ordinary bone cement.

[0045] After mixing gypsum 2g, calcium phosphate 2g and sodium chloride 1g, carry out disinfection to make modifier powder; mix modifier powder with 4ml distilled water to make slurry modifier for later use;

[0046] Take 22.5g of ordinary bone cement in slurry form and mix it with the modifier in slurry form and mix it at high speed for abo...

Embodiment 2

[0049] [embodiment 2] preparation of bone paste

[0050] After mixing gypsum 4g, nano-hydroxyapatite 4g and sodium chloride 1g, modifying agent powder is made; modifying agent powder is mixed with 8ml water, and the modifying agent made into slurry is standby; according to embodiment 1 The method for preparing ordinary bone cement; take 15g of ordinary bone cement in the form of slurry and the above-mentioned modifier in the form of slurry for high-speed mixing for about 1-1.5 minutes, and the bone paste product can be obtained after mixing and stirring evenly.

[0051] Put the above-mentioned bone paste into a syringe, inject it into a plastic tube of ∮8×17mm, and harden after 15-18 minutes (room temperature 18°C), and the hardening temperature is less than 50°C. Then, it was ground into a cylinder of ∮8×16 mm to make 6 samples. Then put the samples on the pressure testing machine, the head speed is 0.5mm / min, take the compression data of 3mm and 5mm respectively, generate t...

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Abstract

The microporous bone cement consists of bone cement 1 weight portion and modifier 0.2-0.7 weight portion mixed together, and its modifier consists of adhesive 30-50 portions, promoter 30-50 weight portions and pore creating agent 10-30 weight portions. The bone paste consists of bone cement 1 weight portion and modifier 0.7-1.3 weight portions mixed together, and its modifier consists of adhesive 30-50 portions, promoter 30-50 weight portions and pore creating agent 10-30 weight portions. The microporous bone cement has most of the mechanical strength of common bone cement maintained, close adhesion between prosthesis and diaphysis and low curing temperature. The bone paste has relatively high mechanical strength and is suitable for repair of severe bone default and tooth.

Description

technical field [0001] The invention relates to the field of orthopedic surgery, in particular to a microporous bone cement and bone plaster. Background technique [0002] The invention of bone cement in the 1960s was one of the great achievements of orthopedic surgery. Bone cement can fill the interface between the human body's bone body and the prosthesis, so that the prosthesis is bonded to the human body's bone body through bone cement, thereby achieving the purpose of replacing damaged joints in the human body. The replaced prosthesis works well at first, but long-term clinical follow-up shows that the prosthesis will loosen over time, which is due to the detachment of the interface between the bone cement and the bone body. Within 10-20 years after surgery, a considerable number of patients require revision surgery, that is, reimplantation of the prosthesis. In addition, the curing temperature of the bone cement during the operation is as high as 90°C, which easily l...

Claims

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Application Information

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IPC IPC(8): A61L27/14A61F2/28
Inventor 周袭明
Owner 北京茵普兰科技发展有限公司
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