Aumeilazole drip pills and its preparation method

Abstract

A coated dripping pill of omeprazole for treating gastric ulcer, duodenal ulcer, stress ulcer, reflux esophagitis, etc is prepared from omeprazole, polyethylene glycol (1000-2000) and polyalkoxyl-40 stearate.

Description

technical field [0001] The invention relates to a pharmaceutical composition suitable for gastric ulcer, duodenal ulcer, stress ulcer, reflux esophagitis and Zoller-Ellison syndrome (gastrinoma), in particular to omeprazole as a raw material The prepared pharmaceutical composition is an oral preparation. Background technique [0002] Peptic ulcer is a common disease all over the world. According to reports from foreign scholars. About 10% of the population suffers from ulcer disease, and the prevalence rates reported in European and American literature are not the same. The highest reaches 13.5%. The lowest was only 5.9%. The difference is quite large. The survey among Australians over the age of 15 shows that the incidence of duodenal ulcer is 3.8%, and the incidence of gastric ulcer is 0.7%. Many hospitals have conducted statistical analysis on outpatient or inpatient cases. From 1978 to 1991, the Department of Internal Medicine of Peking Union Medical College Hospit...

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Problems solved by technology

However, according to the preparation method disclosed in this patent, since the matrix in this invention patent uses PEG4000 and PEG6000, the melting point temperatures of PEG4000 and PEG6000 are all below 60°C, and the optimum temperature for coating is mostly above 60°C. The prepared dripping pills have softened or even melted at the temperature during coating, which will seriously affect the quality of the coating, as well as the quality indicators stipulated by the National Pharmacopoeia for the dropping pills - the weight difference of each pill, the roundness rate Etc., therefore make preparation technology be difficult to meet the process condition of dripping pill and coating simultaneously in industrial production, the qualified product rate of prepared dropping pill is lower, has increased production cost, thereby also indirectly increased patient's medication cost, in The practicality in industrial production is also reduced

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