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Method of preparing cantharides capsule

A technology of mylabris and capsules, which can be used in the fields of capsule delivery, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the problems of high production costs

Inactive Publication Date: 2006-09-20
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to develop a new method for preparing compound mylabris capsules, overcome the high shortcoming of production cost in the prior art, improve product quality, reduce costs, take conveniently, reduce its toxicity as much as possible, and better meet medical needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0191] Using 20g cantharidin, 50g ginseng, 220g astragalus, 210g acanthopanax senticosus, 73g tricorne, 300g barbata, 78g turmeric, 95g dogwood, 95g Ligustrum lucidum, 2.4g bear gall powder, 50g licorice eleven medicinal materials; Crush ginseng, dogwood, Ligustrum lucidum, and Scutellaria barbata into 65 mesh fine powder, sieved, and set aside; can beetle is crushed into 20 mesh or 40 mesh, can beetle is extracted 3 times with chloroform percolation method, and 5 times is added for the first time Measure cantharidin's chloroform solvent. After soaking for 48 hours, release chloroform at a rate of 1ml / min. Add 3 times the amount of chloroform solvent for the second time, and 2 times the amount of chloroform solvent for the third time. The temperature is controlled at 20℃, and chloroform is released each time. The rate is 1ml / min, the extracts are combined, the chloroform is recovered, and concentrated to a thick paste of 1.20 (80℃); the remaining astragalus, tricornu, turmeric, li...

Embodiment 2

[0193] The equipment used and its operating method are basically the same as those in Example 1, except that 23.8g cantharidin, 60g ginseng, 250g astragalus, 250g acanthopanax, 83.5g three-rowed, 318g barbata, 95g turmeric, 119g dogwood , 120g Ligustrum lucidum, 3g bear gall powder, 60g licorice eleven medicinal materials as raw materials, can beetle is extracted 4 times with chloroform percolation at 25℃, the first time add 4 times the amount of can beetle's chloroform solvent, soak for 36 hours and then release Chloroform, add 3 times the amount of chloroform solvent for the second time, add 2 times the amount of chloroform solvent for the third time, and 1 times the amount for the fourth time. The rate of chloroform released each time is 2ml / min; the rest of Astragalus, Triangle, Zedoary, Decoction of licorice and acanthopanax five flavors with water for 3 times. The amount of water added for the first time is 12 times that of the mixture of astragalus, tricornis, turmeric, lic...

Embodiment 3

[0195] The equipment used and its operating method are basically the same as those in Example 1, except that 30g cantharidin, 70g ginseng, 298g astragalus, 297.5g acanthopanax, 110g three-rowed, 332g barbata, 108g turmeric, 136g dogwood, 132g Ligustrum lucidum, 3.5g bear gall powder, 68g licorice eleven medicinal materials were used as raw materials. Cantharidae was percolated and extracted with chloroform for 3 times. For the first time, 4 times the amount of chloroform solvent was added, and chloroform was released after soaking at 30°C for 16 hours. Add 3 times the amount of chloroform solvent for the second time, add 2 times the amount of chloroform solvent for the third time; each time the chloroform is released at a rate of 4ml / min. The remaining astragalus, tricornis, turmeric, licorice, acanthopanax senticosus and five flavors are decocted with water 3 times. The amount of water added at one time is 12 times that of the five-flavor mixture of Astragalus, Triangle, Zedoary,...

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Abstract

A Chinese medicine í«Compound telini fly capsuleí» for treating primary liver cancer, lung cancer, rectum cancer, lymph cancer, and gynecologic cancer is prepared from 10 Chinese-medicinal materials including ginseng, telini fly, astragalus root, etc. Its preparing process is also disclosed.

Description

Technical field [0001] The invention relates to the technical field of manufacturing technology of Chinese patent medicine tablets, and more specifically to a preparation method of compound cantharidin capsules. Background technique [0002] Compound Cantharidum Pills and Compound Cantharidum Tablets are a kind of medicine for dispelling blood, eliminating blood stasis and attacking poison and sore. They are used for diseases such as primary liver cancer, lung cancer, rectal cancer, and malignant lymphoma, with good results. [0003] About compound cantharidin pills and compound cantharidin tablets have been found in patent literature. The Chinese patent document application number 03118520.7 (publication number CN1456222A) publicly reported the preparation method of compound cantharidin tablets. The formula is 39.7-79.4g cantharidin, 99.2-198.4g ginseng, 495.8-991.6g astragalus, 495.8-991.6g acanthopanax, 158.3-316.6g three-sided, 59.5-119g barbata, 158.3-316.6g turmeric, 198.3-...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/48A61P35/00
Inventor 唐德江陈犁
Owner 重庆希尔安药业有限公司
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