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Antineoplastic precharging preparation

A technology of anti-tumor drugs and pre-filled syringes, which is applied in the direction of anti-tumor drugs, drug combinations, and medical preparations containing active ingredients, etc. It can solve the problems of large subcutaneous injection area, inaccurate dosage, and increased pain. Achieve the effects of small unit volume, accurate dosage, and increased sense of security

Inactive Publication Date: 2006-09-27
SINOPHARM A THINK PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In China, prefilled preparations are mostly used in the packaging of biological agents, such as interferon, vaccines, human growth hormone and other fields, but the application in highly toxic anti-tumor drug preparations has not yet appeared.
[0005] At present, the water injection products of tumor drugs in the domestic pharmaceutical market are all packaged in vials or ampoule bottles. When using, it is usually necessary to open the package and then suck it with a syringe, which is easy to cause secondary pollution. The connector of the syringe and the needle cavity Long-term use can easily cause liquid residues, inaccurate usage, toxicity to operating medical personnel, large subcutaneous injection area, increased pain, etc.

Method used

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  • Antineoplastic precharging preparation

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Effect test

Embodiment 1

[0024] Embodiment 1 Illustrates the structure of the prefilled preparation of the antineoplastic drug of the present invention in conjunction with the accompanying drawings

[0025] The antitumor drug prefilled preparation of the present invention is composed of a prefilled syringe and an antitumor drug injection, and the injection is filled into a hollow cylinder jacket of the prefilled syringe.

[0026] See the structure of the prefilled syringe figure 1 . figure 1 Among them, 1 is the jacket, 2 is the piston, 3 is the core rod, 4 is the needle, 5 is the protective cap, 6 is the liquid medicine, 7 is the label, 8 is the aluminum foil, and 9 is the rubber stopper. The jacket 1 is a hollow cylinder, the cone head of the front end is covered with a protective cap 5, and the rear end is open; the hollow cylinder jacket 1 is provided with a piston 2 as a plugging cover for the Chinese medicinal liquid 7 of the jacket 1, which can be placed in the jacket 1. Sliding and sealing, ...

Embodiment 2

[0027] Example 2 The preparation, specifications and technical indicators of the prefilled preparation of the antineoplastic drug of the present invention

[0028] 1. Preparation: first select 1ml of vinorelbine medicinal solution, fill it into a 1ml prefilled syringe, and carry out sterilization treatment; seal the filled medicinal solution with piston 2 and rubber stopper 9 and seal it with aluminum foil 8; Sterilize. The filling procedure of liquid medicine should be completed by mechanized process. The filling, physical inspection, labeling, screwing and plastic sealing of prefilled syringes all adopt automatic production lines.

[0029] 2. The specifications and models can be 1ml, 2ml, 2.5ml, 5ml, and new specifications can be added according to medical and market needs.

[0030] 3. Siliconization treatment and purification and sterilization treatment during preparation:

[0031] 1) Coat 1 can be made of class I borosilicate glass tube that meets the requirements of th...

Embodiment 3

[0035] Embodiment 3 liquid medicine

[0036] Calcium leucovorin, paclitaxel, docetaxel, homoharringtonine, vincristine sulfate, hydroxycamptothecin, etoposide, vindesine sulfate, vinblastine sulfate, vinorelbine bitartrate, Adriamycin hydrochloride, pingyangmycin hydrochloride, epirubicin hydrochloride, pirarubicin hydrochloride, doxorubicin hydrochloride, daunorubicin hydrochloride, cytarabine, fluorouracil, methotrexate, tegafur, Cyclophosphamide, thiotepa, nitrogen mustard hydrochloride, carmustine, nitromustine, ifosfamide, calcium folinate, carboplatin, amsacridine, dacarbazine citrate, cisplatin, mitor hydrochloride Anthraquinone, oxaliplatin, doxifluridine, docetaxel, fludarabine phosphate, bleomycin hydrochloride, clindamycin phosphate, matrine, thymosin, mannan peptide , thiotepa, sodium norcantharidinate, metuximab, mitomycin, actinomycin D, bleomycin, doxorubicin and other antitumor liquids instead of vinorelbine in embodiment 2 The liquid medicine can be used to ...

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Abstract

The present invention is pre-charged antitumor medicine preparation and relates to medicine preparation form. Pre-charged syringe, which has the structure comprising outer sleeve, protecting cap, needle, piston, mandrel and needle sealing rubber plug, is used as the inner package of water soluble antitumor injection. The outer sleeve has inner wall of polypropylene material with less adsorption of medicine, and the needle has diameter of 0.2-0.5 mm. The antitumor medicine may be vinorelbine, taxol, docetaxel, etc. The present invention has less medicine residue, accurate dosage, less pollution risk, convenient packing, lowered medical cost and other advantages.

Description

technical field [0001] The invention relates to a prefilled preparation of medicine, in particular to a prefilled preparation of water injection of antineoplastic medicine. Background technique [0002] Prefilled preparations use prefilled syringes as the inner packaging of the product, and prefilled syringes are a more advanced pharmaceutical packaging material. As a drug packaging system, it puts liquid drugs directly into the syringe for storage, which is simple and convenient to use. At the same time, the syringe itself has a good seal, and the drug can be stored for a long time. Its needle is different from traditional needles and has three bevels, which can reduce the pain of injection for patients. In some drug injection packaging fields, it is rapidly replacing traditional glass ampoules and vials, which not only facilitates the filling of drugs and the use of users, but also has high safety, avoiding the trouble of pumping the drug solution into the syringe. Troub...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J1/05A61J1/06A61M5/28A61K45/00A61P35/00A61P9/08
Inventor 贾志丹合龙王淑娟
Owner SINOPHARM A THINK PHARMA
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