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Method for directly processing pesticide using Camptotheca acuminata

A pesticide and direct technology, applied in the field of pesticide preparation from plant sources, can solve the problems of high price, high price, difficult market acceptance, etc., and achieve the effect of low raw material cost, stable active ingredients, and good control effect

Inactive Publication Date: 2006-10-11
YIFAN AGRI CHEM PLANT ZHEJIANG PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent directly uses a certain purity of camptothecin and its derivatives as the original drug, and manufactures pesticides through formulation processing, which solves the problem of the structure and content of the main chemical components. However, camptothecin and its derivatives have always been used as medicines, and their prices Relatively expensive, the current price of camptothecin with content ≥95% is 35,000 yuan / kg, the price of hydroxycamptothecin with content ≥99% is 380,000 yuan / kg, and the price of other camptothecin derivatives is even higher
Taking camptothecin with a content ≥ 95% as an example, to manufacture a pesticide with 0.2% camptothecin, the raw material cost of camptothecin alone needs more than 70,000 yuan / ton, plus other production costs, it is close to 100,000 yuan / ton tons, its expensive price is difficult to be accepted by the market

Method used

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  • Method for directly processing pesticide using Camptotheca acuminata

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1) Put 100 kg of Camptotheca leaves into the plant crusher, crush for 10 minutes into a slurry, add 100 kg of water, continue crushing for 10 minutes, add 1 kg of sodium dodecylbenzene sulfonate, and use an ultrasonic cell crusher to sonic 30 Minutes, use a 200-mesh dryer to separate the solid and liquid, and collect the liquid part for use;

[0025] 2) Put the liquid collected in 1) into a reaction kettle or a stirring tank, add 5 kg of 46% hydrochloric acid and stir for 30 minutes, add 0.2 kg of calcium lignobenzenesulfonate and 1 kg of wetting agent JFC, and stir for 5 minutes for use. ;

[0026] 3) Concentrate the liquid of 2) to 20 kg through an evaporator or concentrator, use a colloidal grinding wet grinding method, and then further grind it to 95% through a sand mill to obtain a liquid preparation through 3000 mesh, that is: 0.5% Camptotheca acuminata Alkaline water suspension agent.

Embodiment 2

[0028] 1) Put 100 kg of Camptotheca seeds into the plant crusher, crush for 30 minutes into fine powder, add 300 kg of water and 1 kg of NaOH, continue to crush for 20 minutes, use an ultrasonic cell crusher to sonicate for 30 minutes, and use a 200 mesh filter to remove Separate solid and liquid, collect the liquid part for use;

[0029] 2) Put the collected liquid in 1) into a reaction kettle or a stirring tank, add 5 kg of acetic acid and stir for 30 minutes, add 2 kg of calcium dodecylbenzene sulfonate and 1 kg of wetting agent JFC, and stir for 5 minutes for use;

[0030] 3) The liquid obtained in 2) is spray-dried to completely dry it into a solid, and then pulverized by a jet mill to a particle size of 3000-6000 mesh (2.5-5.0 microns) to prepare a solid preparation, namely: 0.3% camptothecin wettability powder.

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Abstract

The invention discloses a method for preparing pesticide by using dendrophilous and relates to field of preparing pesticide by using plant source. The method comprises following steps: (1) disintegrating the fresh or dried leaves, fruits, root, bark and branch of dendrophilous into 100-300 orders with disintegrator; adding base or basic salt after stirring it evenly; disintegrating cell with supersonic wave and getting slurry or separating slurry from solid, collecting liquid for future use; (2) adding inorganic acid or organic acid into got slurry or collected liquid for reaction, regulating pH to be lower than 7, adding pesticide agent after reaction; (3) preparing liquid agent or solid agent through normal preparing process. The invention is characterized by simple process, reduced production cost, about less than five thousand yuan per ton, good effect of pesticide and safe usage.

Description

Technical field [0001] The invention relates to the technical field of methods for preparing pesticides from plant sources, in particular to a method for directly processing a camptotheca into pesticides. Background technique [0002] Camptothca acuminate Decne, Nyssaceae, is a perennial subtropical deciduous broad-leaved tree. This genus is only one species of Camptotheca acuminate. It is a species endemic to my country, mainly distributed in Jiangxi, Zhejiang, Hunan, Hubei, Sichuan Yunnan, Guizhou, Guangxi, Guangdong and other places contain alkaloids in wood, root bark, seeds and leaves. The content in roots is about 0.05%, the content in seeds is about 0.07%, and the content in leaves is about 0.10%. Among them, camptothecin and hydroxycamptothecin are the main components, which have anti-cancer activity and have certain curative effects on liver cancer, gastric cancer, leukemia, bladder cancer, etc. Camptothecin (CPT) is a pyrroloquinoline alkaloid. The chemical structures o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N65/00A01N65/08
Inventor 马建义
Owner YIFAN AGRI CHEM PLANT ZHEJIANG PROV
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