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Albumin nanosphere medicine composition and its preparation method and application method

An albumin and nanosphere technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of not considering side effects, the harm of heavy metal ions and tiny carbon particles, and not paying attention to the problem of drug targeting, etc. Prolonged duration of action, reduced pain sensation, increased stability effects

Inactive Publication Date: 2006-10-11
HUNAN KANGDU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One is that the pain-inducing side effects of tanshinone IIA drugs during injection are not considered, which makes it unbearable for patients, and some patients even refuse to use this drug
The second is that they did not pay attention to the targeting of the treatment site of the drug. Sodium tanshinone IIA sulfonate and sodium tanshinone phosphate are mainly used to treat cardiovascular and cerebrovascular diseases, lung cancer, liver cancer, and leukemia, and should be concentrated in the circulatory system, lungs, and liver. department
The tanshinone IIA drug injection prepared by the prior art adopts the activated carbon process, so there are heavy metal ions and tiny carbon particles adsorbed by the activated carbon caused by the pollution of the activated carbon, which are harmful to the human body

Method used

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  • Albumin nanosphere medicine composition and its preparation method and application method
  • Albumin nanosphere medicine composition and its preparation method and application method
  • Albumin nanosphere medicine composition and its preparation method and application method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Preparation of drug-loaded nanospheres for use.

[0047] Formula is as follows (by weight):

[0048] Albumin 1000-2000;

[0049] Tanshinone IIA salt 20-200;

[0050] Vegetable oil 200000-400000;

[0051] PEG6000 100-200;

[0052] N-(2-mercaptopropionyl)-glycine 20-100;

[0053] Lysine Hydrochloride 20-30.

[0054] 1) Dissolve the amount of albumin in water to make 200g-300g / L albumin aqueous solution, add the amount of sodium tanshinone IIA sulfonate or / and sodium tanshinone IIA phosphate, dissolve completely, then add the amount of hydrochloric acid Lysine, PEG600 (polyethylene glycol 600), N-(2-mercaptopropionyl)-glycine, completely dissolved;

[0055] 2) Add the solution obtained in step 1) into the amount of vegetable oil, stir rapidly at 100-120°C for 10-20 minutes, and then cool to room temperature;

[0056]3) filter the solution obtained in step 2) with a filter membrane with a pore size of 150nm to obtain nanospheres and filtrate, the average diameter of ...

Embodiment 2

[0060] Prepare albumin nanosphere glucose injection, formula is as follows (by weight):

[0061] albumin nanosphere combination drug as tanshinone IIA salt 10;

[0062] Hypromellose 20;

[0063] Polygelatin 1250;

[0064] Antioxidant 40;

[0065] Glucose 12500

[0066] Water 250000.

[0067] The antioxidant refers to any combination of reduced glutathione and cystine.

[0068] The specific preparation method is as follows:

[0069] 1) Take albumin nanosphere combination medicine with a particle diameter of 50-150nm and containing the amount of tanshinone IIA salt.

[0070] 2) Add the amount of polygelatin, antioxidant and glucose into the amount of water for injection at a temperature of 50-60°C, dissolve completely, adjust the pH value to 5.0, and use an ultrafiltration filter with a molecular weight cut-off of 10,000 Daltons Column ultrafiltration, adding the amount of hypromellose (treated at 125° C. for 4 hours before adding) to the ultrafiltrate, completely dissolv...

Embodiment 3

[0079] Prepare albumin nanosphere glucose injection, formula is as follows (by weight):

[0080] Albumin nanosphere combination drug calculated as tanshinone IIA salt 100;

[0081] Hypromellose 10;

[0082] Polygelatin 2500;

[0083] Antioxidant 20;

[0084] Glucose 5000;

[0085] Water 250000.

[0086] The antioxidant refers to one of reduced glutathione, cystine or any combination thereof.

[0087] Mix and dissolve said amount of albumin nanosphere combination drug, hypromellose, polygelatin, antioxidant and glucose in said amount of water, and pack into 1000 sticks.

[0088] The specific preparation method is as follows:

[0089] 4) Take albumin nanosphere combination medicine with a particle size of 50-150nm and containing the amount of tanshinone IIA salt.

[0090] 5) Add the amount of polygelatin, antioxidant and glucose into the amount of water for injection at a temperature of 50-60°C, dissolve completely, adjust the pH value to 5.0, and use an ultrafiltration f...

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Abstract

The invention relates to an albumin nanosphere composition medicament, method for preparing and use, wherein the composition medicament is prepared from the following raw materials (by weight ratio): albumin 1000-2000, tanshinone IIA salt 20-200, vegetable oil 200000-400000, PEG6000 100-200, N-(2-mercapto propionyl)-glycine 20-100, and lysine hydrochloride 20-30.

Description

technical field [0001] The invention relates to an albumin nanosphere combination medicine and its preparation and use method. Background technique [0002] The existing tanshinone IIA drug preparations are conventional injections with antioxidant added, conventional cyclodextrin containing preparations, conventional freeze-dried powders and solid dispersions. One is that the pain-inducing side effects of tanshinone IIA drugs during injection are not considered, which makes it unbearable for patients, and some patients even refuse to use this drug. The second is that they did not pay attention to the targeting of the treatment site of the drug. Sodium tanshinone IIA sulfonate and sodium tanshinone phosphate are mainly used to treat cardiovascular and cerebrovascular diseases, lung cancer, liver cancer, and leukemia, and should be concentrated in the circulatory system, lungs, and liver. department. In the prior art, although liposome preparations and even nanoparticle lipo...

Claims

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Application Information

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IPC IPC(8): A61K38/38A61K31/343A61K31/198A61K47/38A61K47/44A61K47/26A61K9/16A61K9/08A61K9/19A61P35/00A61K47/42
Inventor 蔡海德陈官侃
Owner HUNAN KANGDU PHARMA
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