Calcium phosphate cement

一种磷酸钙、磷酸二钙的技术，应用在磷酸钙矿物领域，能够解决限制使用、固化时间长、不容易注射等问题

Active Publication Date: 2006-10-11
HOWMEDICA OSTEONICS CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, they have a longer curing time and the surgeon must wait for the cement to cure, prolonging the surgical procedure
[0011] Certain other marketed bone cement products such as Synthes Fast Set Putty(R), Lorenz Mimix(R) set fast but are not easily injectable with a syringe or needle, limiting the use of this product in minimally invasive applications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Example 1: Preparation of DCPD containing 40 ppm magnesium.

[0093] (1) prepare the 30% phosphoric acid solution that adds 40ppm magnesium

[0094] In order to prepare the required 30% concentration of orthophosphoric acid (H 3 PO 4 ), in a 5 liter stainless steel beaker, 261 + / - 2 ml of 85% orthophosphoric acid was added to 737 + / - 2 ml of deionized water, and the beaker was placed on a hot plate set at 45°C. Then put a temperature measuring probe in the beaker to measure the temperature of the acid solution, turn on the hot plate, and heat the solution to 45°C. The solution was then stirred at 200 + / - 10 rpm, ensuring that the temperature probe measured the true temperature of the contents of the beaker. While heating the acid solution to 45°C, 0.0413 grams of magnesium oxide (MgO) (equivalent to about 40 ppm magnesium content or about 0.006883% by weight of DCPD), also referred to herein as the magnesium "spigot", was added to the solution. " solution or magnesi...

Embodiment 2

[0131] DCPD containing 60 ppm magnesium was prepared.

[0132] (1) prepare to add 30% phosphoric acid solution that has 60ppm magnesium

[0133] In order to prepare the required 30% concentration of orthophosphoric acid (H 3 PO 4 ), in a 5 liter stainless steel beaker, 261 + / - 2 ml of 85% orthophosphoric acid was added to 737 + / - 2 ml of deionized water, and the beaker was placed on a hot plate set at 47°C. Then put a temperature measuring probe in the beaker to measure the temperature of the acid solution, turn on the hot plate, and heat the solution to 47°C. The solution was then stirred at 200 + / - 10 rpm, ensuring that the temperature probe measured the true temperature of the contents of the beaker. While the acid solution was heated to 47°C, 0.0620 grams of magnesium oxide (MgO) (equivalent to about 60 ppm magnesium content or about 0.0085% by weight of DCPD) was added to the solution. Then, the pH probe and the temperature probe are calibrated and put into the acid s...

Embodiment 3

[0168] Preparation of tetracalcium phosphate (TTCP)

[0169] (1) Preparation of TTCP filter cake

[0170] To form a good TTCP, the TTCP slurry mixture needs to contain a solid to liquid ratio of 50% by weight solution, the solid component comprising 60.15% dicalcium phosphate anhydrous (DCPA) and 39.85% CaCO 3 , the liquid component comprising purified water. To prepare the TTCP "cake" for furnace sintering, ie 3500 grams of cake of TTCP, 2105.25 + / - 0.5 cake DCPA was accurately weighed into a 5 liter clean Buckner flask. Add 1394.75 + / - 0.5 grams of CaCO to this flask 3 . To this powder mixture was added 3.5 liters of deionized water. Table 7 lists the specific weights and percentages of these components.

[0171] Table 7

[0172] raw material

[0173] The Buckner flask was sealed with a suitable rubber stopper and nozzle attachment. The Buckner flask was placed in a Glen Creston Model T10-B turbulent mixer for 20 minutes for uniform mixing....

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Abstract

The present invention relates to a calcium phosphate composition comprising at least one calcium phosphate mineral, at least one reaction retarder, at least one binder and at least one sodium phosphate compound, and to a calcium phosphate cement , comprising a first powder component of stabilized dicalcium phosphate dihydrate containing 10-60 ppm magnesium, a second powder component comprising at least one other calcium phosphate mineral in addition to said stabilized dicalcium phosphate dihydrate, and a third powder component comprising water.

Description

technical field [0001] The present invention relates to the use of calcium phosphate minerals in bone cements and bone fillers and in the preparation of such cements. More specifically, the present invention relates to calcium phosphate bone cements comprising a mixture of tetracalcium phosphate and dicalcium phosphate in aqueous solution, which mixture cures to form a bone cement, the major part of which is hydroxyapatite. Background technique [0002] Hydroxyapatite is a major natural constituent of bone and teeth. Bone cements can be formed by mixing calcium and phosphate precursors in an aqueous solution, which initially forms a paste that hardens into a hydroxyapatite bone cement. Such cements have been found useful for immobilizing fractures and bone defects. Hydroxyapatite has a calcium-to-phosphorus ratio of approximately 1.67, roughly the same ratio as calcium phosphate in natural bone structure. [0003] These pastes can be placed prior to curing where bone frag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B12/02
CPCA61L24/02C04B28/34C04B2111/00836C04B28/344C04B14/366C04B24/06C04B40/065C04B14/304
Inventor M·E·墨菲C·P·克利尔B·J·黑斯G·M·英斯利A·孙一魏D·奥马赫尼P·欣翰
Owner HOWMEDICA OSTEONICS CORP
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