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Fat emulsion of houttuynin analog

A fat emulsion, houttuyniacin technology, applied in the direction of emulsion delivery, anhydride/acid/halide active ingredients, antibacterial drugs, etc. Effect of phagocytic ability of leukocytes, inhibition of lymphocyte migration, and improvement of immunity

Inactive Publication Date: 2006-11-01
JILIN SIHUAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the present inventor finds in the process of applying this method to carry out research, when the consumption of solubilizing agent is bigger, just can obtain acceptable solubilizing effect, and the resolubility of product after freeze-drying (being injection adds injection solvent before use) dissolving) is not ideal
[0006] Lipid emulsion is a new type of drug delivery system. At present, many drugs have tried to use this drug delivery system for clinical application. At the same time, there have been no reports about fat emulsion of houttuyfotin analogues.

Method used

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  • Fat emulsion of houttuynin analog
  • Fat emulsion of houttuynin analog
  • Fat emulsion of houttuynin analog

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The prescription (by 1000ml) of embodiment 1 new houttuyfonate sodium fat emulsion:

[0041] New Houttuyniatin Sodium 2g

[0042] Refined soybean oil 100g

[0043] Egg yolk lecithin 20g

[0044] Glycerin 25g

[0045] Water for injection up to 1000ml.

[0046] Heat neohouttuydin sodium, refined soybean oil, egg yolk lecithin and glycerin at 70-80°C and mix well, add 200ml water for injection to the obtained solution, stir well, add water for injection to make 1000ml , Preliminarily homogenize the solution with a homogenizer, and adjust the pH value to 3.5-4.5 with hydrochloric acid test solution or sodium hydroxide test solution if necessary. Then, under the pressure of 1100Bar, use NS1001L type high-pressure homogenizer (Italy GEA Niro Soavi company) in homogenization 8 times, make the neohouttuyfonate sodium fat emulsion containing 2mg of neohouttuyfonate sodium in every 1ml .

[0047] The fat emulsion can be filled and sealed in small ampoules, each containing 2...

Embodiment 2

[0048] The prescription (according to 1000ml) of embodiment 2 new houttuyniatin sodium fat emulsion:

[0049] New Houttuyniatin Sodium 20g

[0050] Refined soybean oil 150g

[0051] Egg yolk lecithin 25g

[0052] Glycerin 22g

[0053] Oleic acid 3g

[0054] Water for injection up to 1000ml.

[0055] Heat new houttuyfonate sodium, refined soybean oil, egg yolk lecithin, glycerin and oleic acid at 70-80°C and mix well, add 200ml water for injection to the obtained solution, stir well, add water for injection for use Make 1000ml, use a homogenizer to initially homogenize the solution, and adjust the pH value to 4.5-5.5 with hydrochloric acid test solution or sodium hydroxide test solution if necessary. Then, under the pressure of 1100Bar, homogenize 8 times with NS1001L type high-pressure homogenizer to prepare neohouttuyfonate sodium fat emulsion containing 20 mg of neohouttuyfonate sodium per 1 ml.

[0056] The fat emulsion can be filled and sealed in small ampoules, each...

Embodiment 3

[0057] The prescription (according to 1000ml) of embodiment 3 new houttuyniatin sodium fat emulsion:

[0058] Sodium Houttuyniatin 40mg

[0059] Refined soybean oil 100g

[0060] Egg yolk lecithin 10g

[0061] Glycerin 20g

[0062] Water for injection up to 1000ml.

[0063] Heat new houttuyfonate sodium, refined soybean oil and egg yolk lecithin at 60-70°C and mix well, add 200ml water for injection and glycerin to the obtained solution, stir well, add water for injection to make it 1000ml, Preliminarily homogenize the solution with a homogenizer, and adjust the pH value to 6.0-7.0 with hydrochloric acid test solution or sodium hydroxide test solution if necessary. Then, under the pressure of 1100Bar, homogenize 5 times with NS1001L type high-pressure homogenizer to prepare neohouttuyfonate sodium fat emulsion containing 0.04 mg of neohouttuyfonate sodium per 1 ml.

[0064] The fat emulsion can be filled and sealed in infusion bottles, each bottle can hold 100ml, 250ml, 5...

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Abstract

A fatty emulsion with high stability and synergistic function contains houttuyninum analog, plant oil, phasphatide and the water for injection.

Description

【Technical field】 [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a fat emulsion, in particular to a fat emulsion of houttuyfonate analogues. 【Background technique】 [0002] There is a class of important components in the volatile oil of the whole herb Houttuynia cordata of the family Houttuynia genus, that is, houttuyniatin analogues. Staphylococcus aureus, Escherichia coli and Sporothrix have obvious inhibitory effects, which can improve the body's immunity, enhance the phagocytosis of white blood cells in patients, increase the level of serum properdin, and improve the body's non-specific immunity. At present, houttuyniatin analogues have been successfully used in chronic bronchitis and other upper respiratory tract infections, as well as gynecological diseases such as vaginitis, pelvic inflammatory disease, and chronic cervicitis. Typical volatile substances of this type are decanoyl acetaldehyde and lauryl acetaldehyde, both o...

Claims

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Application Information

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IPC IPC(8): A61K31/185A61K9/107A61P31/04
Inventor 杨尚华
Owner JILIN SIHUAN PHARM CO LTD
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