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Synthetic process for water soluble sulfoalkyl ether-beta-cyclic dextrine

A synthesis process and technology of sulfoalkyl ethers, which are applied in the field of new synthesis process of water-soluble sulfoalkyl ether-β-cyclodextrin, can solve the problems of low accuracy, low total yield, increased production of by-products and the like , to achieve high accuracy

Inactive Publication Date: 2006-11-08
TONGLIANG FINE CHEM
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The patent Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof applied by Stella and Rajewski, USP5134127, USP5376645 [the solubilization and application of cyclodextrin derivatives] once reported that in aqueous sodium hydroxide solution, the use of control sulbutyrolactone or The molar ratio of sulfopropiolactone and β-cyclodextrin is different to obtain sulfobutyl ether-β-cyclodextrin or sulfopropyl ether-β-cyclodextrin derivatives with different degrees of substitution; Lu Haojie et al [Lu Haojie, Ruan Zongqin, Ou Qingyu, Synthesis of chiral additive sulfobutyl-β-cyclodextrin and chiral separation by capillary electrophoresis, Journal of Analysis and Testing, 2000, 19(5): 16~19] also carried out two similar methods However, in their method, they are only limited to controlling the average degree of substitution by the addition of sulbutyrolactone or sulpholactone, so it is inevitable that there is a wide range of substitution degrees and the accuracy is not good. high disadvantage
In addition, because there is an excessive amount of strong alkaline substance sodium hydroxide in the reaction system, the raw material sulbutyrolactone or sulpholactone will be partially hydrolyzed to increase the production of by-products, resulting in a lower overall yield and increased separation difficulty. Big

Method used

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  • Synthetic process for water soluble sulfoalkyl ether-beta-cyclic dextrine
  • Synthetic process for water soluble sulfoalkyl ether-beta-cyclic dextrine

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Embodiment 1

[0019]Under stirring, dissolve 10 grams of β-cyclodextrin (8.8 mmol) in 20 mL of anhydrous dioxane solvent, and add 0.24 grams of sodium metal (10.6 mmol) in batches until the sodium metal is completely reacted, and add to the above reaction system 1.8 g of sultone (13.2 mmol) was slowly added dropwise, and the etherification reaction was carried out under reflux at 70° C. for 3 hours. After the reaction was complete, the amorphous solid was separated, washed with methanol three times, and dried. After drying, the solid was dissolved in 100 ml of deionized water, neutralized with 1N hydrochloric acid to pH 8, desalted and purified through a Sephadex column (G-25), the filtrate was concentrated, and freeze-dried to obtain white water-soluble sulfobutyl Ether-β-cyclodextrin 4.7 g (yield about 41%). The average molecular weight is 1307, elemental analysis: measured value C42.75%, H5.96%, S2.71%, Na1.93, C / S=15.77, calculated value (substitution degree is 1.1) C / S=15.7.

Embodiment 2

[0021] Under stirring, dissolve 10 grams of β-cyclodextrin (8.8 mmol) in 20 mL of anhydrous dioxane solvent, add 0.97 grams of sodium metal (42.3 mmol) in batches until the sodium metal is completely reacted, and then add to the above reaction system Slowly add 7.2 g of sultone (52.8 mmol) dropwise, and carry out etherification reaction at 90° C. for 3 hours under reflux reaction. After the reaction is complete, an amorphous solid is separated, washed with methanol three times, and dried. After drying, the solid was dissolved in 150 ml of deionized water, neutralized with 1N sulfuric acid to pH 8, desalted and purified through a Sephadex column (G-25), the filtrate was concentrated, and freeze-dried to obtain white water-soluble sulfobutyl Ether-β-cyclodextrin 8.3 g (yield about 52%). The average molecular weight is 1813, elemental analysis: measured value C39.35%, H5.65%, S7.49%, Na5.52, C / S=5.25, calculated value (substitution degree is 4.3) C / S=5.26.

Embodiment 3

[0023] Under stirring, dissolve 10 grams of β-cyclodextrin (8.8 mmol) in 20 mL of anhydrous dioxane solvent, and add 1.70 grams of sodium metal (73.9 mmol) in batches until the sodium metal is completely reacted, and then add to the above reaction system 12.57 g of sultone (92.4 mmol) was slowly added dropwise, and the reaction was carried out under reflux at 105° C. for etherification for 3 hours. After the reaction was complete, an amorphous solid was separated, washed with methanol three times, and dried. After drying, the solid was dissolved in 200 ml of deionized water, neutralized with 1N hydrochloric acid to pH 8, desalinated and purified by ultrafiltration membrane permeation method (500MWCO fiber ester membrane), the filtrate was concentrated, and freeze-dried to obtain a slightly yellow water-soluble sulfobutane Ether-β-cyclodextrin 11.4 g (yield about 57%). The average molecular weight is 2271, elemental analysis: measured value C37.44%, H5.32%, S10.21%, Na7.26, C / S...

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Abstract

The present invention relates to synthesis process of water soluble sulfoalkyl ether-beta-cyclodextrin. The process includes dissolving certain amount of beta-cyclodextrin in anhydrous dioxane solvent, adding certain amount of metal sodium for complete reaction, dropping certain amount of sulfo butyrolactone or sulfo propiolactone slowly into the reaction system, refluxing at certain temperature for etherification reaction, separating out amorphous solid after finishing the reaction, washing with methanol for several times, drying, dissolving the dried solid in deionized water, neutralization with acid to pH 8, desalting purification, concentrating the filtrate, and freeze drying to obtain white or yellowish water soluble sulfobutyl ether-beta-cyclodextrin or sulfopropyl ether-beta-cyclodextrin.

Description

technical field [0001] The invention relates to a new synthesis process of a water-soluble sulfoalkyl ether-β-cyclodextrin, and belongs to the technical field of synthesis of pharmaceutical auxiliary materials. Background technique [0002] Cyclodextrin (CD for short) is a cyclic oligosaccharide of D-glucose, which is isolated from the reaction of starch cyclodextrin glycosyltransferase, and is formed by β-glucopyranose in chair conformation through α-(1,4) It is connected by glycosidic bonds and has a special non-polar tire-like ring structure. Its chemical structure is as follows: [0003] [0004] Natural cyclodextrins include 6 (n=4, also known as α-CD), 7 (n=5, also known as β-CD), 8 (n=6, also known as γ-CD) chair conformations β-glucopyranose ring. In the field of pharmaceutical formulations, cyclodextrin and its derivatives are known as the perfect "host" body, which can encapsulate various organic and inorganic guest molecules and ...

Claims

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Application Information

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IPC IPC(8): C08B37/16A61K47/40
Inventor 王建华李阳春
Owner TONGLIANG FINE CHEM
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