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Ganoderma spore tablet and preparation process thereof

A technology of Ganoderma lucidum spore powder and spore powder tablet, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, allergic diseases, etc., and can solve problems that affect the quality of medicines, temperature, humidity, and microbial limits exceed the standard. To achieve the effect of controlling product quality, improving product quality and increasing stability

Inactive Publication Date: 2006-12-27
NANJING ZHONGKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Ganoderma lucidum spore powder medicines currently on the market are Ganoderma lucidum spore powder capsules according to the State Drug Administration Standard (Trial) WS-5026 (B-0026)-2004, and the particle size of the Ganoderma lucidum spores is 8.5~11.5×5~6.5μm [9] , after crushing the wall, the surface energy is relatively large. The original technology of Ganoderma lucidum spore powder capsules is that the spores of Ganoderma lucidum are crushed and directly filled into capsules, so the product is easy to absorb moisture. During storage, the moisture is easy to exceed the standard, resulting in microbial limit Exceeding the standard, thus affecting the quality of medicines
In addition, the shell material of capsules is mainly gelatin, which is greatly affected by temperature and humidity.

Method used

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  • Ganoderma spore tablet and preparation process thereof
  • Ganoderma spore tablet and preparation process thereof
  • Ganoderma spore tablet and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] prescription:

[0106] Ganoderma lucidum spore powder 200g

[0107] Calcium hydrogen phosphate 540g

[0108] Polyvinylpyrrolidone 60g

[0109] Magnesium Stearate 9g

[0110] 15% cross-linked polyvinylpyrrolidone aqueous solution 600ml

[0111] Makes 1000 pieces

[0112] Preparation process:

[0113] The ganoderma lucidum spores are taken and ultrafinely pulverized, and the wall breaking rate is greater than 85%. Take broken ganoderma lucidum spore powder, add calcium hydrogen phosphate and polyvinylpyrrolidone as auxiliary materials, mix well, use 15% cross-linked polyvinylpyrrolidone aqueous solution to make soft material, granulate with 16-mesh stainless steel sieve, dry at 70 ° C, and use 16-mesh stainless steel sieve Whole grain, add magnesium stearate and mix evenly, tabletting (as each tablet contains 0.2g of broken Ganoderma lucidum spore powder, calculate tablet weight, about 0.87g) 1000 pieces, film coating (weight gain 4%), to obtain final product.

Embodiment 2

[0115] prescription:

[0116] Ganoderma lucidum spore powder 200g

[0117] Calcium hydrogen phosphate 230g

[0118] Polyvinylpyrrolidone 20g

[0119] Magnesium Stearate 5.5g

[0120] 15% cross-linked polyvinylpyrrolidone aqueous solution 540ml

[0121] Makes 1000 pieces

[0122] Preparation process:

[0123]The ganoderma lucidum spores are taken and ultrafinely pulverized, and the wall breaking rate is greater than 85%. Take broken ganoderma lucidum spore powder, add calcium hydrogen phosphate and polyvinylpyrrolidone as auxiliary materials, mix well, use 15% cross-linked polyvinylpyrrolidone aqueous solution to make soft material, granulate with 16-mesh stainless steel sieve, dry at 80 ° C, and use 16-mesh stainless steel sieve Whole grain, add magnesium stearate and mix evenly, tabletting (as each tablet contains 0.2g of broken ganoderma lucidum spore powder, calculate tablet weight, about 0.52g) 1000 pieces, film coating (weight gain 4%), to obtain final product.

Embodiment 3

[0125] prescription:

[0126] Ganoderma lucidum spore powder 200g

[0127] Calcium hydrogen phosphate 540g

[0128] Polyvinylpyrrolidone 20g

[0129] Magnesium Stearate 8.5g

[0130] 15% cross-linked polyvinylpyrrolidone aqueous solution 540ml

[0131] Makes 1000 pieces

[0132] Preparation process:

[0133] The ganoderma lucidum spores are taken and ultrafinely pulverized, and the wall breaking rate is greater than 85%. Take broken ganoderma lucidum spore powder, add calcium hydrogen phosphate and polyvinylpyrrolidone as auxiliary materials, mix well, use 15% cross-linked polyvinylpyrrolidone aqueous solution to make a soft material, granulate with a 16-mesh stainless steel sieve, dry at 50 ° C, and use a 16-mesh stainless steel sieve Whole grain, add magnesium stearate and mix evenly, tabletting (as each tablet contains 0.2g of broken Ganoderma lucidum spore powder, calculate tablet weight, about 0.83g) 1000 pieces, film coating (weight gain 4%), to obtain final produc...

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Abstract

The invention discloses a glossy ganoderma spore powder slice and preparation process. The glossy ganoderma spore powder slice is prepared of raw material of glossy ganoderma spore powder and assistant material of calcium hydrogen orthophosphate, polyvinylpyrrolidone, magnesium stearate and crosslinking polyvinylpyrrolidone water solution of 15%. The preparation process includes: ultramicro disintegrating lossy ganoderma spore to make break-wall lossy ganoderma spore powder, mixing the powder, calcium hydrogen orthophosphate and polyvinylpyrrolidone and adding 15 % crosslinking polyvinylpyrrolidone water solution to make soft material, preparing particles with 16 mesh sieve, drying at 50-80 DEG C, tidying particles with 16 mesh sieve, adding magnesium stearate, tabletting, packing thin film and getting production. The invention employs specifically assistant material which can reduce influence of determination for glossy ganoderma spore polysaccharide, and employs water-solubility dampproof material thin film which can effectively increase stability of preparation and improve quality of medicament.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a ganoderma lucidum spore powder tablet and a preparation process thereof. Background technique [0002] Ganoderma lucidum spore powder is the spores of Ganoderma Lucidum Karst. Mainly contain polysaccharides, adenine, nucleosides, organic germanium, triterpenoids, ergosterol [1] , vitamin C, E, carotene [2] and trace elements such as zinc, iron, magnesium and manganese [3] . anti-tumor [4][5] , resistance to hypoxia [6] , improve immunity [7] ,anti-oxidation [8] And so on. The Ganoderma lucidum spore powder medicines currently on the market are Ganoderma lucidum spore powder capsules according to the State Drug Administration Standard (Trial) WS-5026 (B-0026)-2004, and the particle size of the Ganoderma lucidum spores is 8.5~11.5×5~6.5μm [9] , after crushing the wall, the surface energy is relatively large. The original technology of Ganoderma lucidum ...

Claims

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Application Information

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IPC IPC(8): A61K36/074A61K9/20A61P37/04A61P39/06
Inventor 冯鹏陈亮钱一帆华克伟
Owner NANJING ZHONGKE PHARMA
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